論文 - 詳細
| RRC ID | 28428 |
|---|---|
| 著者 | Leyva-Castillo JM, Hener P, Michea P, Karasuyama H, Chan S, Soumelis V, Li M. |
| タイトル | Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade. |
| ジャーナル | Nat Commun |
| Abstract |
Thymic stromal lymphopoietin (TSLP) has emerged as a key initiator in Th2 immune responses, but the TSLP-driven immune cascade leading to Th2 initiation remains to be delineated. Here, by dissecting the cellular network triggered by mouse skin TSLP in vivo, we uncover that TSLP-promoted IL-4 induction in CD4(+) T cells in skin-draining lymph nodes is driven by an orchestrated 'DC-T-Baso-T' cascade, which represents a sequential cooperation of dendritic cells (DCs), CD4(+) T cells and basophils. Moreover, we reveal that TSLP-activated DCs prime naive CD4(+) T cells to produce IL-3 via OX40L signalling and demonstrate that the OX40L-IL-3 axis has a critical role in mediating basophil recruitment, CD4(+) T-cell expansion and Th2 priming. These findings thus add novel insights into the cellular network and signal axis underlying the initiation of Th2 immune responses. |
| 巻・号 | 4 |
| ページ | 2847 |
| 公開日 | 2013-1-1 |
| DOI | 10.1038/ncomms3847 |
| PII | ncomms3847 |
| PMID | 24284909 |
| MeSH | Animals Basophils / immunology CD4-Positive T-Lymphocytes / immunology Cytokines / genetics Cytokines / immunology* Dendritic Cells / immunology Female Interleukin-4 / immunology Male Mice Mice, Inbred BALB C Mice, Knockout Skin / cytology Skin / immunology* Th2 Cells / immunology* |
| IF | 12.121 |
| 引用数 | 76 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC02298 |