RRC ID 28428
Author Leyva-Castillo JM, Hener P, Michea P, Karasuyama H, Chan S, Soumelis V, Li M.
Title Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade.
Journal Nat Commun
Abstract Thymic stromal lymphopoietin (TSLP) has emerged as a key initiator in Th2 immune responses, but the TSLP-driven immune cascade leading to Th2 initiation remains to be delineated. Here, by dissecting the cellular network triggered by mouse skin TSLP in vivo, we uncover that TSLP-promoted IL-4 induction in CD4(+) T cells in skin-draining lymph nodes is driven by an orchestrated 'DC-T-Baso-T' cascade, which represents a sequential cooperation of dendritic cells (DCs), CD4(+) T cells and basophils. Moreover, we reveal that TSLP-activated DCs prime naive CD4(+) T cells to produce IL-3 via OX40L signalling and demonstrate that the OX40L-IL-3 axis has a critical role in mediating basophil recruitment, CD4(+) T-cell expansion and Th2 priming. These findings thus add novel insights into the cellular network and signal axis underlying the initiation of Th2 immune responses.
Volume 4
Pages 2847
Published 2013-1-1
DOI 10.1038/ncomms3847
PII ncomms3847
PMID 24284909
MeSH Animals Basophils / immunology CD4-Positive T-Lymphocytes / immunology Cytokines / genetics Cytokines / immunology* Dendritic Cells / immunology Female Interleukin-4 / immunology Male Mice Mice, Inbred BALB C Mice, Knockout Skin / cytology Skin / immunology* Th2 Cells / immunology*
IF 12.121
Times Cited 76
Mice RBRC02298