Reference - Detail
| RRC ID | 28437 |
|---|---|
| Author | Nikaido T, Shimizu A, Ishida N, Sabe H, Teshigawara K, Maeda M, Uchiyama T, Yodoi J, Honjo T. |
| Title | Molecular cloning of cDNA encoding human interleukin-2 receptor. |
| Journal | Nature |
| Abstract |
The human interleukin-2 (IL-2) receptor was purified by affinity chromatography using the anti-Tac monoclonal antibody, and its N-terminal amino acid sequence was determined. Complementary DNA clones were isolated and sequenced to reveal the primary structure of the IL-2 receptor precursor, which has 272 amino acid residues. The receptor is separated into two domains by a putative 19-residue transmembrane region. Two mRNAs (1.4 and 3.5 kilobases) hybridizing to the cDNA clone were found in human T cells bearing the IL-2 receptor. The cDNA directed synthesis of the IL-2 receptor in COS cells. |
| Volume | 311(5987) |
| Pages | 631-5 |
| Published | 1984-10-18 |
| DOI | 10.1038/311631a0 |
| PMID | 6090949 |
| MeSH | Amino Acid Sequence Base Sequence Cloning, Molecular* DNA / isolation & purification DNA / metabolism* DNA Restriction Enzymes Genes* Genetic Vectors Humans Nucleic Acid Hybridization Protein Biosynthesis RNA, Messenger / genetics Receptors, Antigen, T-Cell / genetics* Receptors, Immunologic / genetics* Receptors, Immunologic / isolation & purification Receptors, Interleukin-2 Transcription, Genetic |
| IF | 42.779 |
| Times Cited | 601 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 86 |
| Altmetric score changes over past 6months | 3.0 |
| Resource | |
| DNA material | pKCR. Tac-2A (RDB01171) |