論文 - 詳細
| RRC ID | 28443 |
|---|---|
| 著者 | Nagafuchi A, Shirayoshi Y, Okazaki K, Yasuda K, Takeichi M. |
| タイトル | Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. |
| ジャーナル | Nature |
| Abstract |
E-cadherin is a cell surface glycoprotein responsible for Ca2+-dependent intercellular adhesion between epithelial cells; it is also called uvomorulin, L-CAM (ref. 3), cell-CAM 120/80 (ref.4) or Arc-1 (ref. 5). Because blocking the action of E-cadherin by monoclonal antibodies causes dispersion of compact cell colonies, this molecule is thought to be an important factor for maintenance of multicellular systems. To demonstrate directly that E-cadherin is involved in cell-cell adhesion, we cloned full-length cDNA encoding E-cadherin from F9 cells and introduced it into L fibroblasts deficient in E-cadherin. These L cells acquire strong Ca2+-dependent aggregating activity by expressing the E-cadherin derived from the introduced cDNA and were morphologically transformed so as to form colonies in which cells were tightly connected to each other. |
| 巻・号 | 329(6137) |
| ページ | 341-3 |
| 公開日 | 1987-9-24 |
| DOI | 10.1038/329341a0 |
| PMID | 3498123 |
| MeSH | Amino Acid Sequence Animals Base Sequence Cadherins Calcium / pharmacology Cell Adhesion Cell Line DNA / genetics* DNA, Recombinant Glycoproteins / genetics Glycoproteins / physiology* L Cells / cytology Mice RNA, Messenger / genetics Teratoma Transfection Transformation, Genetic* |
| IF | 42.779 |
| 引用数 | 670 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | Mouse E-cadherin full length cDNA (RDB01184). |