RRC ID 2854
Author Klüver N, Pfennig F, Pala I, Storch K, Schlieder M, Froschauer A, Gutzeit HO, Schartl M.
Title Differential expression of anti-Müllerian hormone (amh) and anti-Müllerian hormone receptor type II (amhrII) in the teleost medaka.
Journal Dev. Dyn.
Abstract In mammals, the anti-Müllerian hormone (Amh) is responsible for the regression of the Müllerian ducts; therefore, Amh is an important factor of male sex differentiation. The amh gene has been cloned in various vertebrates, as well as in several teleost species. To date, all described species show a sexually dimorphic expression of amh during sex differentiation or at least in differentiated juvenile gonads. We have identified the medaka amh ortholog and examined its expression pattern. Medaka amh shows no sexually dimorphic expression pattern. It is expressed in both developing XY male and XX female gonads. In adult testes, amh is expressed in the Sertoli cells and in adult ovaries in granulosa cells surrounding the oocytes, like in mammals. To better understand the function of amh, we cloned the anti-Müllerian hormone receptor type II (amhrII) ortholog and compared its expression pattern with amh, aromatase (cyp19a1), and scp3. During gonad development, amhrII is coexpressed with medaka amh in somatic cells of the gonads and shows no sexually dimorphic expression. Only the expression level of the Amh type II receptor gene was decreased noticeably in adult female gonads. These results suggest that medaka Amh and AmhrII are involved in gonad formation and maintenance in both sexes.
Volume 236(1)
Pages 271-81
Published 2007-1
DOI 10.1002/dvdy.20997
PMID 17075875
MeSH Amino Acid Sequence Animals Anti-Mullerian Hormone Aromatase / genetics Aromatase / metabolism Cloning, Molecular Female Fish Proteins / genetics Fish Proteins / metabolism Gene Expression Regulation, Developmental Glycoproteins / genetics* Glycoproteins / metabolism Male Molecular Sequence Data Oryzias / classification Oryzias / embryology* Oryzias / metabolism Ovary / embryology Ovary / metabolism Phylogeny Receptors, Peptide / genetics* Receptors, Peptide / metabolism Receptors, Transforming Growth Factor beta Sequence Alignment Testicular Hormones / genetics* Testicular Hormones / metabolism Testis / embryology Testis / metabolism
IF 2.004
Times Cited 45
WOS Category ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY
Resource
Medaka d-rR Hd-rR.Y^HNI (MT191) Qurt (MT828)