論文 - 詳細
| RRC ID | 28882 |
|---|---|
| 著者 | Nolte V, Pandey RV, Kofler R, Schlötterer C. |
| タイトル | Genome-wide patterns of natural variation reveal strong selective sweeps and ongoing genomic conflict in Drosophila mauritiana. |
| ジャーナル | Genome Res |
| Abstract |
Although it is well understood that selection shapes the polymorphism pattern in Drosophila, signatures of classic selective sweeps are scarce. Here, we focus on Drosophila mauritiana, an island endemic, which is closely related to Drosophila melanogaster. Based on a new, annotated genome sequence, we characterized the genome-wide polymorphism by sequencing pooled individuals (Pool-seq). We show that the interplay between selection and recombination results in a genome-wide polymorphism pattern characteristic for D. mauritiana. Two large genomic regions (>500 kb) showed the signature of almost complete selective sweeps. We propose that the absence of population structure and limited geographic distribution could explain why such pronounced sweep patterns are restricted to D. mauritiana. Further evidence for strong adaptive evolution was detected for several nucleoporin genes, some of which were not previously identified as genes involved in genomic conflict. Since this adaptive evolution is continuing after the split of D. mauritiana and Drosophila simulans, we conclude that genomic conflict is not restricted to short episodes, but rather an ongoing process in Drosophila. |
| 巻・号 | 23(1) |
| ページ | 99-110 |
| 公開日 | 2013-1-1 |
| DOI | 10.1101/gr.139873.112 |
| PII | gr.139873.112 |
| PMID | 23051690 |
| PMC | PMC3530687 |
| MeSH | Adaptation, Biological Animals Drosophila / genetics* Drosophila Proteins / genetics Evolution, Molecular* Genome, Insect* Nuclear Pore Complex Proteins / genetics Polymorphism, Genetic* Population / genetics Selection, Genetic* |
| IF | 11.093 |
| 引用数 | 50 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | E-18912 |