Reference - Detail
RRC ID | 29074 |
---|---|
Author | Huang E, Blagg SL, Keller T, Katoh M, Shaulsky G, Thompson CR. |
Title | bZIP transcription factor interactions regulate DIF responses in Dictyostelium. |
Journal | Development |
Abstract |
The signalling molecule DIF-1 is required for normal cell fate choice and patterning in Dictyostelium. To understand how these developmental processes are regulated will require knowledge of how cells receive and respond to the DIF-1 signal. Previously, we have described a bZIP transcription factor, DimA, which is required for cells to respond to DIF-1. However, it was unknown whether DimA activity is required to activate the DIF response pathway in certain cells or is a component of the response pathway itself. In this study, we describe the identification of a DimA-related bZIP transcription factor, DimB. Rapid changes in the subcellular localisation of both DimA and DimB in response to DIF-1 suggest that they are directly downstream of the DIF-1 signal. Genetic and biochemical interactions between DimA and DimB provides evidence that their ability to regulate diverse targets in response to DIF-1 is partly due to their ability to form homo- and heterodimeric complexes. DimA and DimB are therefore direct regulators of cellular responses to DIF-1. |
Volume | 133(3) |
Pages | 449-58 |
Published | 2006-2-1 |
DOI | 10.1242/dev.02240 |
PII | 133/3/449 |
PMID | 16410410 |
PMC | PMC3531922 |
MeSH | Amino Acid Sequence Animals Autophagy Basic-Leucine Zipper Transcription Factors / classification Basic-Leucine Zipper Transcription Factors / genetics Basic-Leucine Zipper Transcription Factors / metabolism* Cell Nucleus / metabolism Dictyostelium / cytology Dictyostelium / genetics Dictyostelium / metabolism* Gene Expression Hexanones / metabolism* Molecular Sequence Data Morphogenesis Phylogeny Protozoan Proteins / classification Protozoan Proteins / genetics Protozoan Proteins / metabolism* Recombinant Fusion Proteins / genetics Recombinant Fusion Proteins / metabolism Sequence Alignment Signal Transduction / physiology |
IF | 5.611 |
Times Cited | 55 |
WOS Category | DEVELOPMENTAL BIOLOGY |
Resource | |
Cellular slime molds | S90379 |