RRC ID 29095
著者 Parikh A, Miranda ER, Katoh-Kurasawa M, Fuller D, Rot G, Zagar L, Curk T, Sucgang R, Chen R, Zupan B, Loomis WF, Kuspa A, Shaulsky G.
タイトル Conserved developmental transcriptomes in evolutionarily divergent species.
ジャーナル Genome Biol
Abstract BACKGROUND:Evolutionarily divergent organisms often share developmental anatomies despite vast differences between their genome sequences. The social amoebae Dictyostelium discoideum and Dictyostelium purpureum have similar developmental morphologies although their genomes are as divergent as those of man and jawed fish.
RESULTS:Here we show that the anatomical similarities are accompanied by extensive transcriptome conservation. Using RNA sequencing we compared the abundance and developmental regulation of all the transcripts in the two species. In both species, most genes are developmentally regulated and the greatest expression changes occur during the transition from unicellularity to multicellularity. The developmental regulation of transcription is highly conserved between orthologs in the two species. In addition to timing of expression, the level of mRNA production is also conserved between orthologs and is consistent with the intuitive notion that transcript abundance correlates with the amount of protein required. Furthermore, the conservation of transcriptomes extends to cell-type specific expression.
CONCLUSIONS:These findings suggest that developmental programs are remarkably conserved at the transcriptome level, considering the great evolutionary distance between the genomes. Moreover, this transcriptional conservation may be responsible for the similar developmental anatomies of Dictyostelium discoideum and Dictyostelium purpureum.
巻・号 11(3)
ページ R35
公開日 2010-1-1
DOI 10.1186/gb-2010-11-3-r35
PII gb-2010-11-3-r35
PMID 20236529
PMC PMC2864575
MeSH Base Sequence Biological Evolution* Conserved Sequence / genetics* DNA, Complementary / genetics Dictyostelium / cytology Dictyostelium / genetics* Gene Expression Profiling Gene Expression Regulation, Developmental / genetics* Gene Regulatory Networks / genetics* Molecular Sequence Data RNA, Messenger / genetics RNA, Messenger / metabolism* Sequence Analysis, RNA Species Specificity
IF 10.806
引用数 114
WOS 分野 BIOTECHNOLOGY & APPLIED MICROBIOLOGY GENETICS & HEREDITY
リソース情報
細胞性粘菌 S00436 S00537