| RRC ID |
29100
|
| Author |
Hirose S, Benabentos R, Ho HI, Kuspa A, Shaulsky G.
|
| Title |
Self-recognition in social amoebae is mediated by allelic pairs of tiger genes.
|
| Journal |
Science
|
| Abstract |
Free-living cells of the social amoebae Dictyostelium discoideum can aggregate and develop into multicellular fruiting bodies in which many die altruistically as they become stalk cells that support the surviving spores. Dictyostelium cells exhibit kin discrimination--a potential defense against cheaters, which sporulate without contributing to the stalk. Kin discrimination depends on strain relatedness, and the polymorphic genes tgrB1 and tgrC1 are potential components of that mechanism. Here, we demonstrate a direct role for these genes in kin discrimination. We show that a matching pair of tgrB1 and tgrC1 alleles is necessary and sufficient for attractive self-recognition, which is mediated by differential cell-cell adhesion. We propose that TgrB1 and TgrC1 proteins mediate this adhesion through direct binding. This system is a genetically tractable ancient model of eukaryotic self-recognition.
|
| Volume |
333(6041)
|
| Pages |
467-70
|
| Published |
2011-7-22
|
| DOI |
10.1126/science.1203903
|
| PII |
science.1203903
|
| PMID |
21700835
|
| PMC |
PMC3142563
|
| MeSH |
Alleles
Amino Acid Sequence
Cell Adhesion*
Cell Aggregation
Dictyostelium / genetics*
Dictyostelium / physiology*
Gene Deletion
Genes, Protozoan*
Molecular Sequence Data
Protein Binding
Protozoan Proteins / metabolism*
Spores, Protozoan / physiology
|
| IF |
41.846
|
| Times Cited |
79
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Cellular slime molds |
S00483 |
