RRC ID 29158
著者 Kataoka H, Ochi M, Enomoto K, Yamaguchi A.
タイトル Cloning and embryonic expression patterns of the zebrafish Runt domain genes, runxa and runxb.
ジャーナル Mech Dev
Abstract We isolated zebrafish homologues of the Runt-related transcription factor gene family (Runx family), runxa and runxb, and analyzed their developmental expression patterns. The deduced amino acid sequence of Runxa was highly homologous to that of AML1 (also called CBFA2, PEBP2alphaB or Runx1), a critical regulator of mammalian hematopoiesis expressed in cells of the hematopoietic lineage as well as other tissues. During zebrafish development, the runxa gene was not expressed in hematopoietic tissues but in the olfactory placodes and cells attached to the otic vesicles. We identified three kinds of runxb transcripts, which encoded two types of proteins with different N-terminal regions. The Runxb proteins were highly similar to AML2 (CBFA3, PEBP2alphaC or Runx3). The expression sites of the shared region of runxb mRNAs during development were the trigeminal ganglions, dorsal neurons of the neural tube and the lateral line primordia. These findings show that expression patterns of the zebrafish Runx genes are distinct from that of the mammalian genes.
巻・号 98(1-2)
ページ 139-43
公開日 2000-11-1
DOI 10.1016/s0925-4773(00)00445-7
PII S0925477300004457
PMID 11044618
MeSH Animals Cloning, Molecular Core Binding Factor Alpha 2 Subunit Core Binding Factor alpha Subunits DNA, Complementary / genetics DNA-Binding Proteins / chemistry DNA-Binding Proteins / genetics* Drosophila Proteins Gene Expression Regulation, Developmental Humans In Situ Hybridization Neoplasm Proteins* Nuclear Proteins Proto-Oncogene Proteins* RNA, Messenger / genetics RNA, Messenger / metabolism Transcription Factors / chemistry Transcription Factors / genetics* Zebrafish / embryology* Zebrafish / genetics*
IF 2.126
引用数 37
WOS 分野 DEVELOPMENTAL BIOLOGY
リソース情報
遺伝子材料 apZF-Runxa (RDB06420) pZF-Runxb1 (RDB06421) pZF-Runxb2 (RDB06422) pZF-Runxb3 (RDB06423)