RRC ID 29195
Author Nishizawa M, Kataoka K, Goto N, Fujiwara KT, Kawai S.
Title v-maf, a viral oncogene that encodes a "leucine zipper" motif.
Journal Proc Natl Acad Sci U S A
Abstract We have molecularly cloned the provirus of the avian musculoaponeurotic fibrosarcoma virus AS42. Nucleotide sequence analysis of a biologically active clone of AS42 showed that this virus encodes a viral oncogene, maf. The deduced amino acid sequence of the v-maf gene product contains a "leucine zipper" motif similar to that found in a number of DNA binding proteins, including the gene products of the fos, jun, and myc oncogenes. However, unlike these oncogenes, the cellular maf gene was not transcriptionally activated by growth stimulation of cultured cells.
Volume 86(20)
Pages 7711-5
Published 1989-10-1
DOI 10.1073/pnas.86.20.7711
PMID 2554284
PMC PMC298140
MeSH Amino Acid Sequence Animals Avian Sarcoma Viruses / genetics* Base Sequence Cells, Cultured Chickens Cloning, Molecular Genes, Viral* Molecular Sequence Data Oncogene Proteins, Viral / genetics Oncogenes* Restriction Mapping Sequence Homology, Nucleic Acid Transfection
IF 9.412
Times Cited 225
DNA material pSae-2 (RDB01395)