Reference - Detail
|Author||Nishizawa M, Hayakawa Y, Yanaihara N, Okamoto H.|
|Title||Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat.|
The nucleotide sequence analysis of cloned cDNA for VIP precursor from rat cerebral cortex reveals that the precursor contains both rat VIP and PHI-27. The deduced primary structure of rat VIP is identical with human VIP. The amino acid sequence of rat PHI-27 differs by 4 amino acids from human PHM-27. When each VIP precursor is divided functionally into 6 domains, the amino acid sequence homology between rat and human precursors ranges from 69 to 100%. In contrast, any domain exhibits an essentially equal degree of nucleotide sequence homology.
|MeSH||Amino Acid Sequence Animals Base Sequence Biological Evolution* Cerebral Cortex / analysis DNA DNA, Recombinant Humans Male Nucleic Acid Hybridization Peptide PHI Peptides / genetics Protein Precursors / genetics* RNA, Messenger* Rats Rats, Inbred Strains Vasoactive Intestinal Peptide / genetics*|
|WOS Category||BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY|
|DNA material||pVIP rat-B (RDB01214)|