RRC ID 29201
Author Nishizawa M, Hayakawa Y, Yanaihara N, Okamoto H.
Title Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat.
Journal FEBS Lett
Abstract The nucleotide sequence analysis of cloned cDNA for VIP precursor from rat cerebral cortex reveals that the precursor contains both rat VIP and PHI-27. The deduced primary structure of rat VIP is identical with human VIP. The amino acid sequence of rat PHI-27 differs by 4 amino acids from human PHM-27. When each VIP precursor is divided functionally into 6 domains, the amino acid sequence homology between rat and human precursors ranges from 69 to 100%. In contrast, any domain exhibits an essentially equal degree of nucleotide sequence homology.
Volume 183(1)
Pages 55-9
Published 1985-4-8
DOI 10.1016/0014-5793(85)80953-4
PII 0014-5793(85)80953-4
PMID 3838518
MeSH Amino Acid Sequence Animals Base Sequence Biological Evolution* Cerebral Cortex / analysis DNA DNA, Recombinant Humans Male Nucleic Acid Hybridization Peptide PHI Peptides / genetics Protein Precursors / genetics* RNA, Messenger* Rats Rats, Inbred Strains Vasoactive Intestinal Peptide / genetics*
IF 3.057
Times Cited 227
DNA material pVIP rat-B (RDB01214)