| RRC ID |
29203
|
| Author |
Nakashima N, Tanaka K, Sturm S, Okayama H.
|
| Title |
Fission yeast Rep2 is a putative transcriptional activator subunit for the cell cycle 'start' function of Res2-Cdc10.
|
| Journal |
EMBO J
|
| Abstract |
In the yeast cell cycle 'start' requires sets of the Cdc10/ SWI family of transcriptional factors which activate the MCB cis elements contained in genes essential for S phase progression. Fission yeast possess two such overlapping systems, Res1-Cdc10 and Res2-Cdc10, both of which act to start the mitotic and meiotic cycles. We have recently isolated rep2+ as a multicopy suppressor of a temperature-sensitive cdc10 mutant which encodes a zinc finger protein. Here we show that the Rep2 zinc finger protein is an essential component of the active Res2-Cdc10 transcriptional regulator complex and likely to play a role in the control of cell cycle 'start'. Our data suggest that Rep2 is a transcriptional activator subunit which interacts with the MCB binding subunit complex formed by Res2 and Cdc10.
|
| Volume |
14(19)
|
| Pages |
4794-802
|
| Published |
1995-10-2
|
| DOI |
10.1002/j.1460-2075.1995.tb00161.x
|
| PMID |
7588609
|
| PMC |
PMC394577
|
| MeSH |
Amino Acid Sequence
Base Sequence
Cell Cycle Proteins / metabolism*
Cell Cycle Proteins / physiology
Cloning, Molecular
DNA / metabolism
DNA-Binding Proteins / chemistry
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism
DNA-Binding Proteins / physiology*
Fungal Proteins / genetics
Fungal Proteins / metabolism*
Fungal Proteins / physiology
G1 Phase / genetics*
Genes, Fungal / genetics
Genes, Regulator / genetics
Meiosis / genetics
Mitosis / genetics
Models, Genetic
Molecular Sequence Data
Nitrogen / physiology
Schizosaccharomyces / genetics
Schizosaccharomyces / growth & development
Schizosaccharomyces pombe Proteins*
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Suppression, Genetic
Trans-Activators / chemistry
Trans-Activators / genetics
Trans-Activators / metabolism
Trans-Activators / physiology*
Transcription Factors
Zinc Fingers / genetics
|
| IF |
9.889
|
| Times Cited |
55
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| DNA material |
rep2^+ (RDB01609) |
