論文 - 詳細
| RRC ID | 29488 |
|---|---|
| 著者 | Sugimura T, Jounai K, Ohshio K, Tanaka T, Suwa M, Fujiwara D. |
| タイトル | Immunomodulatory effect of Lactococcus lactis JCM5805 on human plasmacytoid dendritic cells. |
| ジャーナル | Clin Immunol |
| Abstract |
Plasmacytoid dendritic cells (pDCs) play a crucial role in anti-viral immunity through production of large amounts of interferons (IFNs). A previous study revealed the existence of lactic acid bacteria that directly stimulate pDCs in mice. In this study, we demonstrated that Lactococcus lactis JCM5805 activates human pDCs and induces IFN production in vitro. In addition, our randomized, placebo-controlled, double blind test showed that yogurt fermented with L. lactis JCM5805 activated pDC activity in vivo. This effect was greater in low pDC subjects, and their ability to produce IFNs was increased from the beginning. Furthermore, the risk of morbidity from the common cold was suppressed in the L. lactis JCM5805 group compared with the placebo group. In conclusion, intake of L. lactis JCM5805 can directly activate pDCs and increase the ability to produce IFNs in vivo. Therefore, L. lactis JCM5805 may be a beneficial tool to enhance anti-viral immunity in humans. |
| 巻・号 | 149(3) |
| ページ | 509-18 |
| 公開日 | 2013-12-1 |
| DOI | 10.1016/j.clim.2013.10.007 |
| PII | S1521-6616(13)00272-6 |
| PMID | 24239838 |
| MeSH | Adult Cells, Cultured Dendritic Cells / cytology Dendritic Cells / drug effects* Dendritic Cells / immunology Double-Blind Method Female Humans Immunomodulation Interferon-alpha / biosynthesis Interferon-alpha / metabolism Lactococcus lactis / immunology* Male Probiotics / administration & dosage* Surveys and Questionnaires Yogurt |
| IF | 3.368 |
| 引用数 | 27 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 22 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 5805 |