Reference - Detail
| RRC ID | 29684 |
|---|---|
| Author | Tabuchi M, Sakurai T, Mitsuno H, Namiki S, Minegishi R, Shiotsuki T, Uchino K, Sezutsu H, Tamura T, Haupt SS, Nakatani K, Kanzaki R. |
| Title | Pheromone responsiveness threshold depends on temporal integration by antennal lobe projection neurons. |
| Journal | Proc Natl Acad Sci U S A |
| Abstract |
The olfactory system of male moths has an extreme sensitivity with the capability to detect and recognize conspecific pheromones dispersed and greatly diluted in the air. Just 170 molecules of the silkmoth (Bombyx mori) sex pheromone bombykol are sufficient to induce sexual behavior in the male. However, it is still unclear how the sensitivity of olfactory receptor neurons (ORNs) is relayed through the brain to generate high behavioral responsiveness. Here, we show that ORN activity that is subthreshold in terms of behavior can be amplified to suprathreshold levels by temporal integration in antennal lobe projection neurons (PNs) if occurring within a specific time window. To control ORN inputs with high temporal resolution, channelrhodopsin-2 was genetically introduced into bombykol-responsive ORNs. Temporal integration in PNs was only observed for weak inputs, but not for strong inputs. Pharmacological dissection revealed that GABAergic mechanisms inhibit temporal integration of strong inputs, showing that GABA signaling regulates PN responses in a stimulus-dependent fashion. Our results show that boosting of the PNs' responses by temporal integration of olfactory information occurs specifically near the behavioral threshold, effectively defining the lower bound for behavioral responsiveness. |
| Volume | 110(38) |
| Pages | 15455-60 |
| Published | 2013-9-17 |
| DOI | 10.1073/pnas.1313707110 |
| PII | 1313707110 |
| PMID | 24006366 |
| PMC | PMC3780863 |
| MeSH | Animals Animals, Genetically Modified Bombyx / physiology* DNA Primers / genetics Genetic Vectors Interneurons / physiology* Light Male Olfactory Receptor Neurons / metabolism Olfactory Receptor Neurons / physiology* Optogenetics Rhodopsin / genetics Rhodopsin / physiology Sensory Thresholds / physiology Sex Attractants / metabolism* Smell / physiology* Time Factors |
| IF | 9.412 |
| Times Cited | 31 |
| WOS Category | NEUROSCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Silkworms | |