RRC ID 29850
著者 Fassler JS, Tessman I, Tessman ES.
タイトル Lethality of the double mutations rho rep and rho ssb in Escherichia coli.
ジャーナル J Bacteriol
Abstract The similarity of rho mutants to rep and ssb mutants in sensitivity to UV light and in recombination deficiency suggested that the function of the Rho protein might be related to that of Rep and Ssb. In support of that idea, we found that rho rep and rho ssb double mutants are either nonviable, or at best only marginally viable. Viability could be restored by suppressor mutations, one of which mapped either in the rho gene or close to its 5'-end. Rho may thus share a role with Rep and Ssb in replication and the structural maintenance of DNA; a multifunctional Rho protein could account for the diversity of the defects seen in rho mutants, some of which appear to have no relation to the defect in transcription termination.
巻・号 161(2)
ページ 609-14
公開日 1985-2-1
DOI 10.1128/jb.161.2.609-614.1985
PMID 3155723
PMC PMC214926
MeSH Adenosine Triphosphatases / genetics* DNA Helicases* Escherichia coli / genetics* Escherichia coli Proteins Genes, Lethal Mutation* Recombination, Genetic Rho Factor / genetics* Transcription Factors / genetics* Transcription, Genetic Transduction, Genetic
IF 3.006
引用数 30
WOS 分野 MICROBIOLOGY
リソース情報
原核生物(大腸菌) ME8323 ME8324