論文 - 詳細
| RRC ID | 29858 |
|---|---|
| 著者 | Iuchi S, Kuritzkes DR, Lin EC. |
| タイトル | Escherichia coli mutant with altered respiratory control of the frd operon. |
| ジャーナル | J Bacteriol |
| Abstract |
In wild-type Escherichia coli, fumarate reductase encoded by the frd operon is inducible by its substrate in the absence of molecular oxygen and nitrate. Synthesis of this enzyme under permissive conditions requires the fnr+ gene product, which is believed to be a pleiotropic regulatory protein that activates transcription. A spontaneous mutant was isolated in which the expression of the frd operon no longer depended on the presence of fumarate or the fnr+ gene product. Aerobic repression of the operon was abolished, but nitrate repression remained intact. Transductional analysis showed that the mutation was closely linked to the frd locus. The mutant phenotype strongly suggests that repression by molecular oxygen and nitrate is mediated by different mechanisms. |
| 巻・号 | 161(3) |
| ページ | 1023-8 |
| 公開日 | 1985-3-1 |
| DOI | 10.1128/jb.161.3.1023-1028.1985 |
| PMID | 3882660 |
| PMC | PMC215001 |
| MeSH | Anaerobiosis Bacterial Proteins / genetics Escherichia coli / genetics* Escherichia coli / metabolism Gene Expression Regulation / drug effects Genes, Regulator Glycerolphosphate Dehydrogenase / genetics* Multienzyme Complexes / genetics* Mutation Nitrates / pharmacology Operon Succinate Dehydrogenase / genetics* |
| IF | 3.006 |
| 引用数 | 33 |
| WOS 分野 | MICROBIOLOGY |
| リソース情報 | |
| 原核生物(大腸菌) | ME8421 ME8420 |