RRC ID |
2999
|
Author |
Mukai A, Fukai T, Matsumoto Y, Ishikawa J, Hoshino Y, Yazawa K, Harada K, Mikami Y.
|
Title |
Transvalencin Z, a new antimicrobial compound with salicylic acid residue from Nocardia transvalensis IFM 10065.
|
Journal |
J Antibiot (Tokyo)
|
Abstract |
Transvalencin Z was isolated from a culture broth of Nocardia transvalensis IFM 10065, a clinical isolate from a Japanese patient with actinomycotic mycetoma. The transvalencin Z structure was determined using NMR and mass spectrometric analyses. The structure is similar to a partial structure of siderophores such as mycobactins and nocobactins, but the compound has no cytotoxic activity. Transvalencin Z shows a strong antimicrobial activity against Gram-positive bacteria, but shows no activity against Gram-negative bacteria, fungi and tumor cells.
|
Volume |
59(6)
|
Pages |
366-9
|
Published |
2006-6-1
|
DOI |
10.1038/ja.2006.53
|
PMID |
16915823
|
MeSH |
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Fermentation
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Nocardia / metabolism*
Oxazoles / chemistry
Oxazoles / isolation & purification*
Oxazoles / pharmacology
Salicylates / chemistry
Salicylates / isolation & purification*
Salicylates / pharmacology
Salicylic Acid
|
IF |
2.668
|
Times Cited |
34
|
WOS Category
|
PHARMACOLOGY & PHARMACY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
IMMUNOLOGY
MICROBIOLOGY
|
Resource |
Pathogenic microorganisms |
IFM 0150
IFM 0284
IFM 0319
IFM 2057
IFM 5368
IFM 10065
IFM 10489
IFM 40213
IFM 40215 |