RRC ID 2999
Author Mukai A, Fukai T, Matsumoto Y, Ishikawa J, Hoshino Y, Yazawa K, Harada K, Mikami Y.
Title Transvalencin Z, a new antimicrobial compound with salicylic acid residue from Nocardia transvalensis IFM 10065.
Journal J. Antibiot.
Abstract Transvalencin Z was isolated from a culture broth of Nocardia transvalensis IFM 10065, a clinical isolate from a Japanese patient with actinomycotic mycetoma. The transvalencin Z structure was determined using NMR and mass spectrometric analyses. The structure is similar to a partial structure of siderophores such as mycobactins and nocobactins, but the compound has no cytotoxic activity. Transvalencin Z shows a strong antimicrobial activity against Gram-positive bacteria, but shows no activity against Gram-negative bacteria, fungi and tumor cells.
Volume 59(6)
Pages 366-9
Published 2006-6
DOI 10.1038/ja.2006.53
PMID 16915823
MeSH Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / isolation & purification* Anti-Bacterial Agents / pharmacology Fermentation Humans Magnetic Resonance Spectroscopy Mass Spectrometry Nocardia / metabolism* Oxazoles / chemistry Oxazoles / isolation & purification* Oxazoles / pharmacology Salicylates / chemistry Salicylates / isolation & purification* Salicylates / pharmacology Salicylic Acid
IF 2.033
Times Cited 16
WOS Category PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY IMMUNOLOGY MICROBIOLOGY
Resource
Pathogenic microorganisms IFM 0150 IFM 0284 IFM 0319 IFM 2057 IFM 5368 IFM 10065 IFM 10489 IFM 40213 IFM 40215