RRC ID 30008
Author Wallace BJ, Pittard J.
Title Genetic and biochemical analysis of the isoenzymes concerned in the first reaction of aromatic biosynthesis in Escherichia coli.
Journal J Bacteriol
Abstract Mutant strains of Escherichia coli K-12 were isolated possessing mutations which affected the tyrosine-inhibitable 3-deoxy-d-arabinoheptulosonic acid-7-phosphate (DAHP) synthetase, the phenylalanine-inhibitable DAHP synthetase, or the tryptophan-repressible DAHP synthetase. The mutations causing the loss of each of these activities have been mapped and are widely separated from each other on the E. coli chromosome. Chromatography on diethylaminoethyl cellulose columns allowed the recognition of four peaks of activity.
Volume 93(1)
Pages 237-44
Published 1967-1-1
DOI 10.1128/jb.93.1.237-244.1967
PMID 5335890
PMC PMC314994
MeSH Amino Acids / biosynthesis* Chromatography Chromosome Mapping* Enzyme Repression Escherichia coli / enzymology* Escherichia coli / isolation & purification* Isoenzymes / analysis* Ligases / analysis* Mutation Phenylalanine / pharmacology Tryptophan / pharmacology Tyrosine / pharmacology
IF 3.006
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Prokaryotes E. coli JE5588 ME5324 ME8637