Reference - Detail
| RRC ID | 30407 |
|---|---|
| Author | Tei H, Nihonmatsu I, Yokokura T, Ueda R, Sano Y, Okuda T, Sato K, Hirata K, Fujita SC, Yamamoto D. |
| Title | pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor. |
| Journal | Proc Natl Acad Sci U S A |
| Abstract |
Studies on sevenless and bride of sevenless genes have revealed that the R8 cell plays a key role in the fate of the R7 photoreceptor cell, presenting on its surface an inductive cue to which R7 responds. sev-independent induction of R7 cells has been reported in the seven-up mutation, which appears to transform R1 and R6 cells to R7 cells. We have induced recessive mutations in a gene pokkuri (pok; pokkuri is a Japanese word that means "dropping dead") that lead to overproduction of R7 cells with rather minor effects on outer photoreceptors and R8 cells. Pok protein may function as a transcription factor, as the predicted amino acid sequence contains a region similar to the consensus established for the E-26-specific (Ets) domain. |
| Volume | 89(15) |
| Pages | 6856-60 |
| Published | 1992-8-1 |
| DOI | 10.1073/pnas.89.15.6856 |
| PMID | 1495974 |
| PMC | PMC49603 |
| MeSH | Amino Acid Sequence Animals Base Sequence Crosses, Genetic DNA-Binding Proteins* Drosophila / genetics* Drosophila / physiology Eye Proteins / genetics* Female Genes Genetic Carrier Screening Genotype Homozygote Humans Male Molecular Sequence Data Mosaicism Photoreceptor Cells / cytology Photoreceptor Cells / physiology* Protein-Tyrosine Kinases / genetics Proto-Oncogene Protein c-ets-2 Proto-Oncogene Proteins / genetics* Proto-Oncogene Proteins c-ets Proto-Oncogenes* Repressor Proteins* Restriction Mapping Sequence Homology, Nucleic Acid Trans-Activators* Transcription Factors* |
| IF | 9.412 |
| Times Cited | 69 |
| WOS Category | MULTIDISCIPLINARY SCIENCES |
| Resource | |
| Drosophila | DGRC#109074 |