Reference - Detail
| RRC ID | 30415 |
|---|---|
| Author | Fujikawa K, Fort FL, Samejima K, Sakamoto Y. |
| Title | Genotoxic potency in Drosophila melanogaster of selected aromatic amines and polycyclic aromatic hydrocarbons as assayed in the DNA repair test. |
| Journal | Mutat Res |
| Abstract |
Drosophila melanogaster stock consisting of meiotic recombination deficient (Rec-) double mutant mei-9a mei-41D5 males and Rec+ females was exposed at the larval stage to an aromatic amine or a polycyclic aromatic hydrocarbon. After emergence as adult flies, the males and the females were scored separately. When the treatment caused a dose-dependent reduction in the male to female ratio from the control level; the experiment was repeated with a larval stock consisting of Rec+ males and Rec+ females under comparable conditions. A preferential killing effect upon Rec- larvae was taken as evidence of DNA damaging effect of the test compound. Among 16 compounds tested, 1-AP, B(a)P, 2-AF, DAF, 4-AAF, 2-AAF, 1-AA, 2-AA, DMA, B(a)A and DMBA were registered as positive; Py and 3-MC were weakly positive; and B(e)P, Fluo and Ant were negative. The selective killing effects of the compounds in each of the pyrene, fluorene and anthracene series varied drastically as a function of structure in a way similar to that reported for the genotoxicity in Drosophila and the carcinogenicity in rodents. The Drosophila DNA repair assay will serve as a simple adjunct to the already available means for studying the genotoxic potency of aromatic amines and polycyclic aromatic hydrocarbons. |
| Volume | 290(2) |
| Pages | 175-82 |
| Published | 1993-12-1 |
| DOI | 10.1016/0027-5107(93)90157-b |
| PII | 0027-5107(93)90157-B |
| PMID | 7694108 |
| MeSH | 2-Acetylaminofluorene / analogs & derivatives 2-Acetylaminofluorene / toxicity 9,10-Dimethyl-1,2-benzanthracene / toxicity Amines / toxicity* Animals Anthracenes / toxicity Benz(a)Anthracenes / toxicity Benzo(a)pyrene / toxicity DNA Repair* Dose-Response Relationship, Drug Drosophila melanogaster / drug effects* Drosophila melanogaster / genetics Female Fluorenes / toxicity Genes, Insect / drug effects* Larva / drug effects Male Methylcholanthrene / toxicity Mutagens / toxicity* Polycyclic Compounds / toxicity* Pyrenes / toxicity Sex Ratio |
| IF | 2.463 |
| Times Cited | 49 |
| WOS Category | TOXICOLOGY GENETICS & HEREDITY |
| Altmetric score |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#109611 |