Reference - Detail
| RRC ID | 30444 |
|---|---|
| Author | Inoue H, Tateno M, Fujimura-Kamada K, Takaesu G, Adachi-Yamada T, Ninomiya-Tsuji J, Irie K, Nishida Y, Matsumoto K. |
| Title | A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK. |
| Journal | EMBO J |
| Abstract |
In cultured mammalian cells, the p38 mitogen-activated protein kinase (MAPK) pathway is activated in response to a variety of environmental stresses. How ever, there is little evidence from in vivo studies to demonstrate a role for this pathway in the stress response. We identified a Drosophila MAPK kinase kinase (MAPKKK), D-MEKK1, which can activate p38 MAPK. D-MEKK1 is structurally similar to the mammalian MEKK4/MTK1 MAPKKK. D-MEKK1 kinase activity was activated in animals under conditions of high osmolarity. Drosophila mutants lacking D-MEKK1 were hypersensitive to environmental stresses, including elevated temperature and increased osmolarity. In these D-MEKK1 mutants, activation of Drosophila p38 MAPK in response to stress was poor compared with activation in wild-type animals. These results suggest that D-MEKK1 regulation of the p38 MAPK pathway is critical for the response to environmental stresses in Drosophila. |
| Volume | 20(19) |
| Pages | 5421-30 |
| Published | 2001-10-1 |
| DOI | 10.1093/emboj/20.19.5421 |
| PMID | 11574474 |
| PMC | PMC125648 |
| MeSH | Adaptation, Biological Amino Acid Sequence Animals Drosophila / enzymology* Environment Enzyme Activation MAP Kinase Signaling System* Mitogen-Activated Protein Kinases / metabolism* Molecular Sequence Data Protein Serine-Threonine Kinases / metabolism* Sequence Homology, Amino Acid p38 Mitogen-Activated Protein Kinases |
| IF | 9.889 |
| Times Cited | 64 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | F1000Research |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#109805 |