RRC ID |
30450
|
著者 |
Inoue S, Shimoda M, Nishinokubi I, Siomi MC, Okamura M, Nakamura A, Kobayashi S, Ishida N, Siomi H.
|
タイトル |
A role for the Drosophila fragile X-related gene in circadian output.
|
ジャーナル |
Curr Biol
|
Abstract |
Mutations that abolish expression of an X-linked gene, FMR1, result in the pathogenesis of fragile X syndrome, the most common form of inherited mental retardation. To understand the normal function of the FMR1 protein, we have produced fly strains bearing deletions in a Drosophila homolog of FMR1 (dfmr1). Since fragile X patients show a number of abnormal behaviors including sleep problems, we investigated whether a loss-of-function mutation of dfmr1 affect circadian behavior. Here we show that under constant darkness (DD), a lack of dfmr1 expression causes arrhythmic locomotor activity, but in light:dark cycles, their behavioral rhythms appear normal. In addition, the clock-controlled eclosion rhythm is normal in DFMR1-deficient flies. These results suggest that DFMR1 plays a critical role in the circadian output pathway regulating locomotor activity in Drosophila.
|
巻・号 |
12(15)
|
ページ |
1331-5
|
公開日 |
2002-8-6
|
DOI |
10.1016/s0960-9822(02)01036-9
|
PII |
S0960-9822(02)01036-9
|
PMID |
12176363
|
MeSH |
Animals
Circadian Rhythm / genetics*
Drosophila / genetics
Drosophila / physiology*
Drosophila Proteins*
Fragile X Mental Retardation Protein
Fragile X Syndrome / genetics*
Gene Deletion
Humans
Models, Animal
RNA-Binding Proteins / genetics*
Time Factors
X Chromosome*
|
IF |
9.601
|
引用数 |
82
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
リソース情報 |
ショウジョウバエ |
DGRC#109026 |