RRC ID 30450
著者 Inoue S, Shimoda M, Nishinokubi I, Siomi MC, Okamura M, Nakamura A, Kobayashi S, Ishida N, Siomi H.
タイトル A role for the Drosophila fragile X-related gene in circadian output.
ジャーナル Curr Biol
Abstract Mutations that abolish expression of an X-linked gene, FMR1, result in the pathogenesis of fragile X syndrome, the most common form of inherited mental retardation. To understand the normal function of the FMR1 protein, we have produced fly strains bearing deletions in a Drosophila homolog of FMR1 (dfmr1). Since fragile X patients show a number of abnormal behaviors including sleep problems, we investigated whether a loss-of-function mutation of dfmr1 affect circadian behavior. Here we show that under constant darkness (DD), a lack of dfmr1 expression causes arrhythmic locomotor activity, but in light:dark cycles, their behavioral rhythms appear normal. In addition, the clock-controlled eclosion rhythm is normal in DFMR1-deficient flies. These results suggest that DFMR1 plays a critical role in the circadian output pathway regulating locomotor activity in Drosophila.
巻・号 12(15)
ページ 1331-5
公開日 2002-8-6
DOI 10.1016/s0960-9822(02)01036-9
PII S0960-9822(02)01036-9
PMID 12176363
MeSH Animals Circadian Rhythm / genetics* Drosophila / genetics Drosophila / physiology* Drosophila Proteins* Fragile X Mental Retardation Protein Fragile X Syndrome / genetics* Gene Deletion Humans Models, Animal RNA-Binding Proteins / genetics* Time Factors X Chromosome*
IF 9.601
引用数 82
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
ショウジョウバエ DGRC#109026