Reference - Detail
| RRC ID | 30450 |
|---|---|
| Author | Inoue S, Shimoda M, Nishinokubi I, Siomi MC, Okamura M, Nakamura A, Kobayashi S, Ishida N, Siomi H. |
| Title | A role for the Drosophila fragile X-related gene in circadian output. |
| Journal | Curr Biol |
| Abstract |
Mutations that abolish expression of an X-linked gene, FMR1, result in the pathogenesis of fragile X syndrome, the most common form of inherited mental retardation. To understand the normal function of the FMR1 protein, we have produced fly strains bearing deletions in a Drosophila homolog of FMR1 (dfmr1). Since fragile X patients show a number of abnormal behaviors including sleep problems, we investigated whether a loss-of-function mutation of dfmr1 affect circadian behavior. Here we show that under constant darkness (DD), a lack of dfmr1 expression causes arrhythmic locomotor activity, but in light:dark cycles, their behavioral rhythms appear normal. In addition, the clock-controlled eclosion rhythm is normal in DFMR1-deficient flies. These results suggest that DFMR1 plays a critical role in the circadian output pathway regulating locomotor activity in Drosophila. |
| Volume | 12(15) |
| Pages | 1331-5 |
| Published | 2002-8-6 |
| DOI | 10.1016/s0960-9822(02)01036-9 |
| PII | S0960-9822(02)01036-9 |
| PMID | 12176363 |
| MeSH | Animals Circadian Rhythm / genetics* Drosophila / genetics Drosophila / physiology* Drosophila Proteins* Fragile X Mental Retardation Protein Fragile X Syndrome / genetics* Gene Deletion Humans Models, Animal RNA-Binding Proteins / genetics* Time Factors X Chromosome* |
| IF | 9.601 |
| Times Cited | 82 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
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| Total number of mentions | 0 |
| Resource | |
| Drosophila | DGRC#109026 |