RRC ID 30455
Author Lukacsovich T, Yuge K, Awano W, Asztalos Z, Kondo S, Juni N, Yamamoto D.
Title The ken and barbie gene encoding a putative transcription factor with a BTB domain and three zinc finger motifs functions in terminalia development of Drosophila.
Journal Arch Insect Biochem Physiol
Abstract Mutations in the ken and barbie locus are accompanied by the malformation of terminalia in adult Drosophila. Male and female genitalia often remain inside the body, and the same portions of genitalia and analia are missing in a fraction of homozygous flies. Rotated and/or duplicated terminalia are also observed. Terminalia phenotypes are enhanced by mutations in the gap gene tailless, the homeobox gene caudal, and the decapentaplegic gene that encodes a TGFbeta-like morphogen. The ken and barbie gene encodes a protein with three CCHH-type zinc finger motifs that are conserved in several transcription factors such as Krüppel and BCL-6. All defects in ken and barbie mutants are fully rescued by the expression of a wild-type genomic construct, which establishes the causality between phenotypes and the gene.
Volume 54(2)
Pages 77-94
Published 2003-10-1
DOI 10.1002/arch.10105
PMID 14518006
MeSH Acetyl-CoA C-Acetyltransferase / biosynthesis Acetyl-CoA C-Acetyltransferase / genetics Amino Acid Sequence Animals Base Sequence DNA-Binding Proteins / chemistry DNA-Binding Proteins / genetics* Drosophila / anatomy & histology Drosophila / embryology Drosophila / genetics* Drosophila / growth & development* Female Gene Expression Regulation, Developmental / genetics Genes / genetics Genitalia / growth & development* Male Molecular Sequence Data RNA, Messenger / analysis RNA, Messenger / biosynthesis Sequence Homology, Amino Acid Sex Differentiation / genetics Transcription Factors / chemistry Transcription Factors / genetics* Zinc Fingers / genetics* beta-Galactosidase / biosynthesis
IF 1.536
Times Cited 16
Drosophila DGRC#109040 DGRC#109041 DGRC#109042 DGRC#109043 DGRC#109044 DGRC#109045 DGRC#109046 DGRC#109047 DGRC#109048