| RRC ID |
30455
|
| Author |
Lukacsovich T, Yuge K, Awano W, Asztalos Z, Kondo S, Juni N, Yamamoto D.
|
| Title |
The ken and barbie gene encoding a putative transcription factor with a BTB domain and three zinc finger motifs functions in terminalia development of Drosophila.
|
| Journal |
Arch Insect Biochem Physiol
|
| Abstract |
Mutations in the ken and barbie locus are accompanied by the malformation of terminalia in adult Drosophila. Male and female genitalia often remain inside the body, and the same portions of genitalia and analia are missing in a fraction of homozygous flies. Rotated and/or duplicated terminalia are also observed. Terminalia phenotypes are enhanced by mutations in the gap gene tailless, the homeobox gene caudal, and the decapentaplegic gene that encodes a TGFbeta-like morphogen. The ken and barbie gene encodes a protein with three CCHH-type zinc finger motifs that are conserved in several transcription factors such as Krüppel and BCL-6. All defects in ken and barbie mutants are fully rescued by the expression of a wild-type genomic construct, which establishes the causality between phenotypes and the gene.
|
| Volume |
54(2)
|
| Pages |
77-94
|
| Published |
2003-10-1
|
| DOI |
10.1002/arch.10105
|
| PMID |
14518006
|
| MeSH |
Acetyl-CoA C-Acetyltransferase / biosynthesis
Acetyl-CoA C-Acetyltransferase / genetics
Amino Acid Sequence
Animals
Base Sequence
DNA-Binding Proteins / chemistry
DNA-Binding Proteins / genetics*
Drosophila / anatomy & histology
Drosophila / embryology
Drosophila / genetics*
Drosophila / growth & development*
Female
Gene Expression Regulation, Developmental / genetics
Genes / genetics
Genitalia / growth & development*
Male
Molecular Sequence Data
RNA, Messenger / analysis
RNA, Messenger / biosynthesis
Sequence Homology, Amino Acid
Sex Differentiation / genetics
Transcription Factors / chemistry
Transcription Factors / genetics*
Zinc Fingers / genetics*
beta-Galactosidase / biosynthesis
|
| IF |
1.536
|
| Times Cited |
16
|
|
WOS Category
|
ENTOMOLOGY
PHYSIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Drosophila |
DGRC#109040
DGRC#109041
DGRC#109042
DGRC#109043
DGRC#109044
DGRC#109045
DGRC#109046
DGRC#109047
DGRC#109048 |
