論文 - 詳細
| RRC ID | 30485 |
|---|---|
| 著者 | Hirano Y, Masuda T, Naganos S, Matsuno M, Ueno K, Miyashita T, Horiuchi J, Saitoe M. |
| タイトル | Fasting launches CRTC to facilitate long-term memory formation in Drosophila. |
| ジャーナル | Science |
| Abstract |
Canonical aversive long-term memory (LTM) formation in Drosophila requires multiple spaced trainings, whereas appetitive LTM can be formed after a single training. Appetitive LTM requires fasting prior to training, which increases motivation for food intake. However, we found that fasting facilitated LTM formation in general; aversive LTM formation also occurred after single-cycle training when mild fasting was applied before training. Both fasting-dependent LTM (fLTM) and spaced training-dependent LTM (spLTM) required protein synthesis and cyclic adenosine monophosphate response element-binding protein (CREB) activity. However, spLTM required CREB activity in two neural populations--mushroom body and DAL neurons--whereas fLTM required CREB activity only in mushroom body neurons. fLTM uses the CREB coactivator CRTC, whereas spLTM uses the coactivator CBP. Thus, flies use distinct LTM machinery depending on their hunger state. |
| 巻・号 | 339(6118) |
| ページ | 443-6 |
| 公開日 | 2013-1-25 |
| DOI | 10.1126/science.1227170 |
| PII | 339/6118/443 |
| PMID | 23349290 |
| MeSH | Animals CREB-Binding Protein / metabolism Cyclic AMP Response Element-Binding Protein / metabolism Cycloheximide / pharmacology Drosophila / physiology* Drosophila Proteins / biosynthesis Drosophila Proteins / metabolism* Fasting* Memory, Long-Term* / drug effects Mushroom Bodies / physiology Neurons / physiology Protein Synthesis Inhibitors / pharmacology Transcription Factors / metabolism* |
| IF | 41.846 |
| 引用数 | 71 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 43 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#109871 |