RRC ID 30637
Author Melo JA, Ruvkun G.
Title Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses.
Journal Cell
Abstract The nematode C. elegans is attracted to nutritious bacteria and is repelled by pathogens and toxins. Here we show that RNAi and toxin-mediated disruption of core cellular activities, including translation, respiration, and protein turnover, stimulate behavioral avoidance of normally attractive bacteria. RNAi of these and other essential processes induces expression of detoxification and innate immune effectors, even in the absence of toxins or pathogens. Disruption of core processes in non-neuronal tissues was sufficient to stimulate aversion behavior, revealing a neuroendocrine axis of control that additionally required serotonergic and Jnk kinase signaling pathways. We propose that surveillance pathways overseeing core cellular activities allow animals to detect invading pathogens that deploy toxins and virulence factors to undermine vital host functions. Variation in cellular surveillance and endocrine pathways controlling behavior, detoxification, and immunity selected by past toxin or microbial interactions could underlie aberrant responses to foods, medicines, and microbes.
Volume 149(2)
Pages 452-66
Published 2012-4-13
DOI 10.1016/j.cell.2012.02.050
PII S0092-8674(12)00346-7
PMID 22500807
PMC PMC3613046
MeSH Animals Bacteria / metabolism Bacterial Toxins Caenorhabditis elegans / cytology Caenorhabditis elegans / immunology Caenorhabditis elegans / microbiology* Caenorhabditis elegans / physiology* Cell Physiological Phenomena Host-Pathogen Interactions* Immunity, Innate MAP Kinase Signaling System Neurosecretory Systems / metabolism RNA Interference Signal Transduction Xenobiotics / metabolism*
IF 38.637
Times Cited 185
C.elegans tm4067