論文 - 詳細
| RRC ID | 30637 |
|---|---|
| 著者 | Melo JA, Ruvkun G. |
| タイトル | Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses. |
| ジャーナル | Cell |
| Abstract |
The nematode C. elegans is attracted to nutritious bacteria and is repelled by pathogens and toxins. Here we show that RNAi and toxin-mediated disruption of core cellular activities, including translation, respiration, and protein turnover, stimulate behavioral avoidance of normally attractive bacteria. RNAi of these and other essential processes induces expression of detoxification and innate immune effectors, even in the absence of toxins or pathogens. Disruption of core processes in non-neuronal tissues was sufficient to stimulate aversion behavior, revealing a neuroendocrine axis of control that additionally required serotonergic and Jnk kinase signaling pathways. We propose that surveillance pathways overseeing core cellular activities allow animals to detect invading pathogens that deploy toxins and virulence factors to undermine vital host functions. Variation in cellular surveillance and endocrine pathways controlling behavior, detoxification, and immunity selected by past toxin or microbial interactions could underlie aberrant responses to foods, medicines, and microbes. |
| 巻・号 | 149(2) |
| ページ | 452-66 |
| 公開日 | 2012-4-13 |
| DOI | 10.1016/j.cell.2012.02.050 |
| PII | S0092-8674(12)00346-7 |
| PMID | 22500807 |
| PMC | PMC3613046 |
| MeSH | Animals Bacteria / metabolism Bacterial Toxins Caenorhabditis elegans / cytology Caenorhabditis elegans / immunology Caenorhabditis elegans / microbiology* Caenorhabditis elegans / physiology* Cell Physiological Phenomena Host-Pathogen Interactions* Immunity, Innate MAP Kinase Signaling System Neurosecretory Systems / metabolism RNA Interference Signal Transduction Xenobiotics / metabolism* |
| IF | 38.637 |
| 引用数 | 185 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 19 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 線虫 | tm4067 |