| RRC ID |
30640
|
| Author |
Watson E, MacNeil LT, Arda HE, Zhu LJ, Walhout AJM.
|
| Title |
Integration of metabolic and gene regulatory networks modulates the C. elegans dietary response.
|
| Journal |
Cell
|
| Abstract |
Expression profiles are tailored according to dietary input. However, the networks that control dietary responses remain largely uncharacterized. Here, we combine forward and reverse genetic screens to delineate a network of 184 genes that affect the C. elegans dietary response to Comamonas DA1877 bacteria. We find that perturbation of a mitochondrial network composed of enzymes involved in amino acid metabolism and the TCA cycle affects the dietary response. In humans, mutations in the corresponding genes cause inborn diseases of amino acid metabolism, most of which are treated by dietary intervention. We identify several transcription factors (TFs) that mediate the changes in gene expression upon metabolic network perturbations. Altogether, our findings unveil a transcriptional response system that is poised to sense dietary cues and metabolic imbalances, illustrating extensive communication between metabolic networks in the mitochondria and gene regulatory networks in the nucleus.
|
| Volume |
153(1)
|
| Pages |
253-66
|
| Published |
2013-3-28
|
| DOI |
10.1016/j.cell.2013.02.050
|
| PII |
S0092-8674(13)00284-5
|
| PMID |
23540702
|
| PMC |
PMC3817025
|
| MeSH |
Acyl-CoA Dehydrogenase / metabolism
Animals
Betaproteobacteria
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans Proteins / metabolism
Diet
Escherichia coli
Gene Regulatory Networks*
Humans
Insulin / metabolism
Metabolic Networks and Pathways*
Metabolism, Inborn Errors
Mitochondria / metabolism
Phosphotransferases (Alcohol Group Acceptor) / metabolism
RNA Interference
Signal Transduction
Transcription Factors / metabolism
|
| IF |
38.637
|
| Times Cited |
59
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| C.elegans |
tm4695 |
