論文 - 詳細
| RRC ID | 30651 |
|---|---|
| 著者 | Maures TJ, Booth LN, Benayoun BA, Izrayelit Y, Schroeder FC, Brunet A. |
| タイトル | Males shorten the life span of C. elegans hermaphrodites via secreted compounds. |
| ジャーナル | Science |
| Abstract |
How an individual's longevity is affected by the opposite sex is still largely unclear. In the nematode Caenorhabditis elegans, the presence of males accelerated aging and shortened the life span of individuals of the opposite sex (hermaphrodites), including long-lived or sterile hermaphrodites. The male-induced demise could occur without mating and required only exposure of hermaphrodites to medium in which males were once present. Such communication through pheromones or other diffusible substances points to a nonindividual autonomous mode of aging regulation. The male-induced demise also occurred in other species of nematodes, suggesting an evolutionary conserved process whereby males may induce the disposal of the opposite sex to save resources for the next generation or to prevent competition from other males. |
| 巻・号 | 343(6170) |
| ページ | 541-4 |
| 公開日 | 2014-1-31 |
| DOI | 10.1126/science.1244160 |
| PII | science.1244160 |
| PMID | 24292626 |
| PMC | PMC4126796 |
| MeSH | Animals Biological Evolution Caenorhabditis elegans / drug effects Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Carrier Proteins / genetics Culture Media, Conditioned / metabolism Culture Media, Conditioned / pharmacology Female Gene Expression Regulation Genes, Helminth / genetics Longevity / drug effects Longevity / genetics Longevity / physiology* Male Peptide Hormones / genetics RNA Interference |
| IF | 41.846 |
| 引用数 | 84 |
| WOS 分野 | MULTIDISCIPLINARY SCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 57 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1053 |