RRC ID 30651
Author Maures TJ, Booth LN, Benayoun BA, Izrayelit Y, Schroeder FC, Brunet A.
Title Males shorten the life span of C. elegans hermaphrodites via secreted compounds.
Journal Science
Abstract How an individual's longevity is affected by the opposite sex is still largely unclear. In the nematode Caenorhabditis elegans, the presence of males accelerated aging and shortened the life span of individuals of the opposite sex (hermaphrodites), including long-lived or sterile hermaphrodites. The male-induced demise could occur without mating and required only exposure of hermaphrodites to medium in which males were once present. Such communication through pheromones or other diffusible substances points to a nonindividual autonomous mode of aging regulation. The male-induced demise also occurred in other species of nematodes, suggesting an evolutionary conserved process whereby males may induce the disposal of the opposite sex to save resources for the next generation or to prevent competition from other males.
Volume 343(6170)
Pages 541-4
Published 2014-1-31
DOI 10.1126/science.1244160
PII science.1244160
PMID 24292626
PMC PMC4126796
MeSH Animals Biological Evolution Caenorhabditis elegans / drug effects Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Carrier Proteins / genetics Culture Media, Conditioned / metabolism Culture Media, Conditioned / pharmacology Female Gene Expression Regulation Genes, Helminth / genetics Longevity / drug effects Longevity / genetics Longevity / physiology* Male Peptide Hormones / genetics RNA Interference
IF 41.058
Times Cited 43
WOS Category MULTIDISCIPLINARY SCIENCES
Resource
C.elegans tm1053