RRC ID |
30671
|
著者 |
Lemaitre B, Kromer-Metzger E, Michaut L, Nicolas E, Meister M, Georgel P, Reichhart JM, Hoffmann JA.
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タイトル |
A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.
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ジャーナル |
Proc Natl Acad Sci U S A
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Abstract |
In this paper we report a recessive mutation, immune deficiency (imd), that impairs the inducibility of all genes encoding antibacterial peptides during the immune response of Drosophila. When challenged with bacteria, flies carrying this mutation show a lower survival rate than wild-type flies. We also report that, in contrast to the antibacterial peptides, the antifungal peptide drosomycin remains inducible in a homozygous imd mutant background. These results point to the existence of two different pathways leading to the expression of two types of target genes, encoding either the antibacterial peptides or the antifungal peptide drosomycin.
|
巻・号 |
92(21)
|
ページ |
9465-9
|
公開日 |
1995-10-10
|
DOI |
10.1073/pnas.92.21.9465
|
PMID |
7568155
|
PMC |
PMC40822
|
MeSH |
Animals
Anti-Bacterial Agents / metabolism*
Antimicrobial Cationic Peptides*
Bacterial Infections / immunology
Base Sequence
Drosophila / genetics
Drosophila / immunology*
Drosophila Proteins
Gene Expression Regulation*
Genes, Insect / genetics*
Genes, Recessive / genetics
Genes, Reporter
Glycopeptides / genetics
Glycopeptides / metabolism
Insect Hormones / genetics
Insect Hormones / metabolism
Insect Proteins*
Male
Molecular Sequence Data
Mutation
Mycoses / immunology
Peptides / genetics
Peptides / metabolism*
Protein Binding
Regulatory Sequences, Nucleic Acid
Survival Analysis
|
IF |
9.412
|
引用数 |
417
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
ショウジョウバエ |
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