RRC ID 30671
Author Lemaitre B, Kromer-Metzger E, Michaut L, Nicolas E, Meister M, Georgel P, Reichhart JM, Hoffmann JA.
Title A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.
Journal Proc Natl Acad Sci U S A
Abstract In this paper we report a recessive mutation, immune deficiency (imd), that impairs the inducibility of all genes encoding antibacterial peptides during the immune response of Drosophila. When challenged with bacteria, flies carrying this mutation show a lower survival rate than wild-type flies. We also report that, in contrast to the antibacterial peptides, the antifungal peptide drosomycin remains inducible in a homozygous imd mutant background. These results point to the existence of two different pathways leading to the expression of two types of target genes, encoding either the antibacterial peptides or the antifungal peptide drosomycin.
Volume 92(21)
Pages 9465-9
Published 1995-10-10
DOI 10.1073/pnas.92.21.9465
PMID 7568155
PMC PMC40822
MeSH Animals Anti-Bacterial Agents / metabolism* Antimicrobial Cationic Peptides* Bacterial Infections / immunology Base Sequence Drosophila / genetics Drosophila / immunology* Drosophila Proteins Gene Expression Regulation* Genes, Insect / genetics* Genes, Recessive / genetics Genes, Reporter Glycopeptides / genetics Glycopeptides / metabolism Insect Hormones / genetics Insect Hormones / metabolism Insect Proteins* Male Molecular Sequence Data Mutation Mycoses / immunology Peptides / genetics Peptides / metabolism* Protein Binding Regulatory Sequences, Nucleic Acid Survival Analysis
IF 9.58
Times Cited 417