論文 - 詳細
| RRC ID | 30824 |
|---|---|
| 著者 | Ma X, Shao Y, Zheng H, Li M, Li W, Xue L. |
| タイトル | Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila. |
| ジャーナル | Cell Death Dis |
| Abstract |
Loss of the cell polarity gene could cooperate with oncogenic Ras to drive tumor growth and invasion, which critically depends on the c-Jun N-terminal Kinase (JNK) signaling pathway in Drosophila. By performing a genetic screen, we have identified Src42A, the ortholog of mammalian Src, as a key modulator of both Ras(V12)/lgl(-/-) triggered tumor invasion and loss of cell polarity gene-induced cell migration. Our genetic study further demonstrated that the Bendless (Ben)/dUev1a ubiquitin E2 complex is an essential regulator of Src42A-induced, JNK-mediated cell migration. Furthermore, we showed that ectopic Ben/dUev1a expression induced invasive cell migration along with increased MMP1 production in wing disc epithelia. Moreover, Ben/dUev1a could cooperate with Ras(V12) to promote tumor overgrowth and invasion. In addition, we found that the Ben/dUev1a complex is required for ectopic Src42A-triggered cell death and endogenous Src42A-dependent thorax closure. Our data not only provide a mechanistic insight into the role of Src in development and disease but also propose a potential oncogenic function for Ubc13 and Uev1a, the mammalian homologs of Ben and dUev1a. |
| 巻・号 | 4(10) |
| ページ | e864 |
| 公開日 | 2013-10-17 |
| DOI | 10.1038/cddis.2013.392 |
| PII | cddis2013392 |
| PMID | 24136228 |
| PMC | PMC3920939 |
| MeSH | Animals Cell Death Cell Movement Drosophila Proteins / metabolism* Drosophila melanogaster / cytology* Drosophila melanogaster / enzymology* Enzyme Activation JNK Mitogen-Activated Protein Kinases / metabolism* MAP Kinase Signaling System Neoplasm Invasiveness Neoplasm Metastasis Neoplasms / enzymology* Neoplasms / pathology* Proto-Oncogene Proteins pp60(c-src) / metabolism* Transcription Factors / metabolism* Ubiquitin-Conjugating Enzymes / metabolism* Wings, Animal / enzymology Wings, Animal / growth & development Wings, Animal / pathology ras Proteins / metabolism |
| IF | 6.304 |
| 引用数 | 33 |
| WOS 分野 | CELL BIOLOGY |
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| 各媒体での言及数の合計 | 0 |
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