論文 - 詳細
| RRC ID | 30825 |
|---|---|
| 著者 | Jouandin P, Ghiglione C, Noselli S. |
| タイトル | Starvation induces FoxO-dependent mitotic-to-endocycle switch pausing during Drosophila oogenesis. |
| ジャーナル | Development |
| Abstract |
When exposed to nutrient challenge, organisms have to adapt their physiology in order to balance reproduction with adult fitness. In mammals, ovarian follicles enter a massive growth phase during which they become highly dependent on gonadotrophic factors and nutrients. Somatic tissues play a crucial role in integrating these signals, controlling ovarian follicle atresia and eventually leading to the selection of a single follicle for ovulation. We used Drosophila follicles as a model to study the effect of starvation on follicle maturation. Upon starvation, Drosophila vitellogenic follicles adopt an 'atresia-like' behavior, in which some slow down their development whereas others enter degeneration. The mitotic-to-endocycle (M/E) transition is a critical step during Drosophila oogenesis, allowing the entry of egg chambers into vitellogenesis. Here, we describe a specific and transient phase during M/E switching that is paused upon starvation. The Insulin pathway induces the pausing of the M/E switch, blocking the entry of egg chambers into vitellogenesis. Pausing of the M/E switch involves a previously unknown crosstalk between FoxO, Cut and Notch that ensures full reversion of the process and rapid resumption of oogenesis upon refeeding. Our work reveals a novel genetic mechanism controlling the extent of the M/E switch upon starvation, thus integrating metabolic cues with development, growth and reproduction. |
| 巻・号 | 141(15) |
| ページ | 3013-21 |
| 公開日 | 2014-8-1 |
| DOI | 10.1242/dev.108399 |
| PII | dev.108399 |
| PMID | 24993942 |
| PMC | PMC6514422 |
| MeSH | Animals Cell Cycle Cytoplasm / metabolism Drosophila Proteins / genetics Drosophila Proteins / physiology* Drosophila melanogaster / physiology* Female Food Deprivation* Forkhead Transcription Factors / genetics Forkhead Transcription Factors / physiology* Gene Expression Regulation Green Fluorescent Proteins / metabolism Mitosis* Oocytes / cytology Oogenesis / physiology* Ovarian Follicle / metabolism Ovulation Ploidies Receptors, Notch / metabolism Signal Transduction Vitellogenesis |
| IF | 5.611 |
| 引用数 | 20 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |