Reference - Detail
| RRC ID | 30825 |
|---|---|
| Author | Jouandin P, Ghiglione C, Noselli S. |
| Title | Starvation induces FoxO-dependent mitotic-to-endocycle switch pausing during Drosophila oogenesis. |
| Journal | Development |
| Abstract |
When exposed to nutrient challenge, organisms have to adapt their physiology in order to balance reproduction with adult fitness. In mammals, ovarian follicles enter a massive growth phase during which they become highly dependent on gonadotrophic factors and nutrients. Somatic tissues play a crucial role in integrating these signals, controlling ovarian follicle atresia and eventually leading to the selection of a single follicle for ovulation. We used Drosophila follicles as a model to study the effect of starvation on follicle maturation. Upon starvation, Drosophila vitellogenic follicles adopt an 'atresia-like' behavior, in which some slow down their development whereas others enter degeneration. The mitotic-to-endocycle (M/E) transition is a critical step during Drosophila oogenesis, allowing the entry of egg chambers into vitellogenesis. Here, we describe a specific and transient phase during M/E switching that is paused upon starvation. The Insulin pathway induces the pausing of the M/E switch, blocking the entry of egg chambers into vitellogenesis. Pausing of the M/E switch involves a previously unknown crosstalk between FoxO, Cut and Notch that ensures full reversion of the process and rapid resumption of oogenesis upon refeeding. Our work reveals a novel genetic mechanism controlling the extent of the M/E switch upon starvation, thus integrating metabolic cues with development, growth and reproduction. |
| Volume | 141(15) |
| Pages | 3013-21 |
| Published | 2014-8-1 |
| DOI | 10.1242/dev.108399 |
| PII | dev.108399 |
| PMID | 24993942 |
| PMC | PMC6514422 |
| MeSH | Animals Cell Cycle Cytoplasm / metabolism Drosophila Proteins / genetics Drosophila Proteins / physiology* Drosophila melanogaster / physiology* Female Food Deprivation* Forkhead Transcription Factors / genetics Forkhead Transcription Factors / physiology* Gene Expression Regulation Green Fluorescent Proteins / metabolism Mitosis* Oocytes / cytology Oogenesis / physiology* Ovarian Follicle / metabolism Ovulation Ploidies Receptors, Notch / metabolism Signal Transduction Vitellogenesis |
| IF | 5.611 |
| Times Cited | 20 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | |