Reference - Detail
| RRC ID | 30902 |
|---|---|
| Author | Ohno T, Yamaguchi N. |
| Title | Life span elongation of Werner's syndrome fibroblasts by co-culture with origin-defective SV-40 DNA transformed cells. |
| Journal | Hum Genet |
| Abstract |
Co-culturing with origin-defective SV40 DNA-injected transformants, we succeeded in activating the limited growth potential of late-phase-II fibroblasts from patients with Werner's syndrome (WS cells). Residual life spans of three WS cell lines increased 2.3-5.6 fold. Co-culture with normal IMR-90 cells showed variable effects on different WS cell lines. |
| Volume | 68(3) |
| Pages | 209-10 |
| Published | 1984-1-1 |
| DOI | 10.1007/BF00418390 |
| PMID | 6094336 |
| MeSH | Aging* Cell Survival Cell Transformation, Viral* Cells, Cultured DNA Replication Growth Substances / physiology Humans Peptides / physiology Simian virus 40 Transforming Growth Factors Werner Syndrome / pathology* |
| IF | 5.743 |
| Times Cited | 7 |
| WOS Category | GENETICS & HEREDITY |
| Resource | |
| DNA material | pSVtsA58 ori (-) (RDB01126) |