論文 - 詳細
RRC ID | 30902 |
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著者 | Ohno T, Yamaguchi N. |
タイトル | Life span elongation of Werner's syndrome fibroblasts by co-culture with origin-defective SV-40 DNA transformed cells. |
ジャーナル | Hum Genet |
Abstract |
Co-culturing with origin-defective SV40 DNA-injected transformants, we succeeded in activating the limited growth potential of late-phase-II fibroblasts from patients with Werner's syndrome (WS cells). Residual life spans of three WS cell lines increased 2.3-5.6 fold. Co-culture with normal IMR-90 cells showed variable effects on different WS cell lines. |
巻・号 | 68(3) |
ページ | 209-10 |
公開日 | 1984-1-1 |
DOI | 10.1007/BF00418390 |
PMID | 6094336 |
MeSH | Aging* Cell Survival Cell Transformation, Viral* Cells, Cultured DNA Replication Growth Substances / physiology Humans Peptides / physiology Simian virus 40 Transforming Growth Factors Werner Syndrome / pathology* |
IF | 5.743 |
引用数 | 7 |
WOS 分野 | GENETICS & HEREDITY |
リソース情報 | |
遺伝子材料 | pSVtsA58 ori (-) (RDB01126) |