論文 - 詳細
| RRC ID | 311 |
|---|---|
| 著者 | Takata K, Inoue YH, Hirose F, Murakami S, Shimanouchi K, Sakimoto I, Sakaguchi K. |
| タイトル | Spatio-temporal expression of Drosophila mitochondrial transcription factor A during development. |
| ジャーナル | Cell Biol Int |
| Abstract |
We previously reported cloning of the Drosophila mitochondrial transcription factor A (D-mtTFA) gene, and characterization of a recombinant protein. In this report, the expression and distribution patterns of D-mtTFA during development are described. D-mtTFA mRNA and its protein product were found to be abundant in cells of tissues undergoing both proliferation and polytenization. Furthermore, a DRE-like sequence present in the D-mtTFA gene showed promotor activity in Drosophila Kc cells. In addition, D-mtTFA was detected in brain throughout the developmental process, as well as in non-proliferating tissues, such as flight muscle and cardia, and was also found in spermatids of imagos. D-mtTFA possesses a nuclear-targeting sequence, and is present in the nucleus at the syncytial stage, where bundles of 64 spermatids are present during spermatogenesis. The results suggest that D-mtTFA not only contributes to the mitochondrial DNA transcription and replication system, but also has a role in cell proliferation and development, including spermatogenesis. |
| 巻・号 | 27(4) |
| ページ | 361-74 |
| 公開日 | 2003-4-1 |
| DOI | 10.1016/s1065-6995(02)00355-4 |
| PII | S1065699502003554 |
| PMID | 12788053 |
| MeSH | Animals Base Sequence / physiology DNA-Binding Proteins* Drosophila Proteins / biosynthesis* Drosophila Proteins / genetics Drosophila melanogaster Gene Expression Regulation, Developmental / physiology* Male Mitochondrial Proteins* Mutation Nuclear Proteins / biosynthesis* Nuclear Proteins / genetics Spermatogenesis / physiology Time Factors Transcription Factors / biosynthesis* Transcription Factors / genetics |
| IF | 2.571 |
| 引用数 | 5 |
| WOS 分野 | CELL BIOLOGY |
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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