| RRC ID |
31714
|
| 著者 |
Burger E, Miyaji M, Sano A, Calich VL, Nishimura K, Lenzi HL.
|
| タイトル |
Histopathology of paracoccidioidomycotic infection in athymic and euthymic mice: a sequential study.
|
| ジャーナル |
Am J Trop Med Hyg
|
| Abstract |
We report the comparative and sequential histologic analysis of lesions developed by Paracoccidioides brasiliensis-infected athymic and euthymic BALB/c mice, using conventional and specific stain to characterize the morphology of fungi and inflammatory cells as well as the extracellular matrix patterns. In both groups, neutrophils and macrophages were the predominant cells; macrophage transition to giant and epithelioid cells was observed. Degenerated fungi and fungal dust were associated with local neutropil infiltration and the presence of pseudoxantomatous macrophages. Paracoccidioides brasiliensis are always found within an extracellular matrix microenvironment. The main differences between lesions developed by nu/+ and nude (nu/nu) mice resided in the more pronounced encapsulating tendency in the former ones. In both groups of animals, lesions in several organs were associated with extensive hemopoiesis. At the first week of infection, there was evidence of fungal destruction and control of its proliferation in both mouse groups. At the fourth and seventh weeks, nu/+ mice maintained the control of the infection, as shown by the scarce numbers of budding yeast cells, while experimental nu/nu mice showed a tumor-like progression of the disease with a striking increase in fungal load in many organs (e.g., omental and mesenteric milky spots, lymph nodes, spleen), some of which present their structure replaced by granulomatous lesions.
|
| 巻・号 |
55(2)
|
| ページ |
235-42
|
| 公開日 |
1996-8-1
|
| DOI |
10.4269/ajtmh.1996.55.235
|
| PMID |
8780467
|
| MeSH |
Animals
Brain / pathology
Child, Preschool
Extracellular Matrix / pathology
Female
Humans
Liver / microbiology
Liver / pathology
Lymph Nodes / pathology
Macrophages
Male
Mesentery / pathology
Mice
Mice, Inbred BALB C
Mice, Nude
Neutrophils
Omentum / pathology
Paracoccidioidomycosis / immunology
Paracoccidioidomycosis / pathology*
Specific Pathogen-Free Organisms
Spleen / pathology
|
| IF |
2.126
|
| 引用数 |
18
|
|
WOS 分野
|
TROPICAL MEDICINE
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
|
| リソース情報 |
| 病原微生物 |
IFM 41621
IFM 1629
IFM 46466 |
