RRC ID 31721
Author Yazawa K, Mikami Y, Sakamoto T, Ueno Y, Morisaki N, Iwasaki S, Furihata K.
Title Inactivation of the macrolide antibiotics erythromycin, midecamycin, and rokitamycin by pathogenic Nocardia species.
Journal Antimicrob. Agents Chemother.
Abstract A survey of five Nocardia spp. with respect to susceptibility towards three macrolides (erythromycin, rokitamycin, and midecamycin) showed that the Nocardia spp. have different susceptibility profiles. Most of the resistance was due to the inactivation of the macrolides by phosphorylation, glycosylation, reduction, deacylation, or a combination thereof.
Volume 38(9)
Pages 2197-9
Published 1994-9
PMID 7811046
PMC PMC284711
MeSH Biotransformation Erythromycin / pharmacokinetics* Erythromycin / pharmacology Glycosylation Inactivation, Metabolic Leucomycins / pharmacokinetics* Leucomycins / pharmacology Microbial Sensitivity Tests Miocamycin / analogs & derivatives* Miocamycin / pharmacokinetics Miocamycin / pharmacology Nocardia / drug effects* Nocardia / metabolism* Oxidation-Reduction Phosphorylation
IF 4.715
Times Cited 8
Pathogenic microorganisms IFM 0236 IFM 0239 IFM 0284 IFM 0310 IFM 0339