RRC ID 31758
Author Hirano K, Kubota T, Tsuda M, Mikami Y, Kobayashi J.
Title Pyrinodemins B-D, potent cytotoxic bis-pyridine alkaloids from marine sponge amphimedon sp.
Journal Chem Pharm Bull (Tokyo)
Abstract New bis-pyridine alkaloids, pyrinodemins B-D (1-3), have been isolated together with pyrinodemin A (4) and related 3-alkyl pyridine alkaloids 5-8 from the Okinawan marine sponge Amphimedon sp. and the structures were elucidated from spectroscopic data. Pyrinodemins B-D (1-3) showed potent cytotoxicity, while compounds 5-8 exhibited antimicrobial activity.
Volume 48(7)
Pages 974-7
Published 2000-7-1
DOI 10.1248/cpb.48.974
PMID 10923825
MeSH Alkaloids / chemistry Alkaloids / isolation & purification* Alkaloids / pharmacology Animals Anti-Bacterial Agents Anti-Infective Agents / chemistry Anti-Infective Agents / isolation & purification* Anti-Infective Agents / pharmacology Bacteria / drug effects Candida albicans / drug effects Porifera / chemistry* Pyridines / chemistry Pyridines / isolation & purification Pyridines / pharmacology
IF 1.416
Times Cited 46
WOS Category CHEMISTRY, MULTIDISCIPLINARY CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY
Resource
Pathogenic microorganisms IFM 2057 IFM 40213 IFM 40215