Reference - Detail
| RRC ID | 31800 |
|---|---|
| Author | Ochi H, Tamai T, Nagano H, Kawaguchi A, Sudou N, Ogino H. |
| Title | Evolution of a tissue-specific silencer underlies divergence in the expression of pax2 and pax8 paralogues. |
| Journal | Nat Commun |
| Abstract |
Recent studies underscore a role for the differential degeneration of enhancers in the evolutionary diversification of paralogue expression. However, no one has reported evidence for the involvement of innovative cis-regulatory changes. Here we show that silencer innovation diversified expression of the vertebrate paralogues, pax2 and pax8. pax2 shows multi-tissue expression, as does the ancestral amphioxus orthologue, pax2/5/8, whereas pax8 expression localizes to a subset of pax2-expressing tissues. We reveal that both pax2 and pax8 retain ancestral enhancers capable of directing pax2-like, multi-tissue expression. However, a silencer within the pax8 proximal promoter suppresses pleiotropic enhancer activity outside the pax8-expressing tissues. In contrast, the combination of the pax2 proximal promoter with either the pax8 or pax2 enhancer recapitulates pax2-like expression, as in the amphioxus pax2/5/8 promoter. We propose that silencer innovation, rather than enhancer degeneration, was crucial for the divergent expression of paralogues with pleiotropic enhancers inherited from their common progenitor. |
| Volume | 3 |
| Pages | 848 |
| Published | 2012-5-22 |
| DOI | 10.1038/ncomms1851 |
| PII | ncomms1851 |
| PMID | 22617288 |
| MeSH | Animals Animals, Genetically Modified Enhancer Elements, Genetic / genetics Humans PAX2 Transcription Factor / metabolism* Paired Box Transcription Factors / metabolism* Promoter Regions, Genetic / genetics Vertebrates Xenopus |
| IF | 12.121 |
| Times Cited | 20 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Clawed frogs / Newts | Ivory Coast line |