| RRC ID |
31863
|
| Author |
Fukushima K, Arai T, Mori Y, Tsuboi M, Suzuki M.
|
| Title |
Studies on peptide antibiotics, leucinostatins. I. Separation, physico-chemical properties and biological activities of leucinostatins A and B.
|
| Journal |
J Antibiot (Tokyo)
|
| Abstract |
Leucinostatin, a peptide antibiotic, was separated by silica gel and alumina column chromatography into two related components designated as leucinostatin A hydrochloride (C61H111-N11O13.HCl) and leucinostatin B hydrochloride (C61H109N11O13.HCl). Physico-chemical as well as biological properties of the two separated components were analyzed. These properties pointed to closely resembling chemical structures.
|
| Volume |
36(12)
|
| Pages |
1606-12
|
| Published |
1983-12-1
|
| DOI |
10.7164/antibiotics.36.1606
|
| PMID |
6662804
|
| MeSH |
Animals
Anti-Bacterial Agents* / isolation & purification*
Anti-Bacterial Agents* / toxicity
Antimicrobial Cationic Peptides
Chromatography, High Pressure Liquid / methods
Chromatography, Thin Layer / methods
Drug Evaluation, Preclinical
Fungi / drug effects
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Mitochondria, Liver / drug effects
Mitochondria, Liver / metabolism
Oxygen Consumption / drug effects
Peptides / isolation & purification
Peptides / toxicity
Rats
Spectrophotometry, Infrared
Structure-Activity Relationship
|
| IF |
2.668
|
| Times Cited |
39
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
MICROBIOLOGY
IMMUNOLOGY
|
| Resource |
| Pathogenic microorganisms |
IFM 40005
IFM 40006
IFM 40007
IFM 40009 |
