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  • Search Condition : Filter (MeSH = Drug Evaluation, Preclinical)
Species Resource
Prokaryotes E. coli JW1653 Identification of inhibitors of the E. coli cyclopropane fatty acid synthase from the screening of a chemical library: In vitro and in vivo studies.
DNA material , Yeast pDUAL-FFH1c (RDB06142) , S. pombe ORFeome Clones. Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling.
DNA material pDUAL-FFH1c (RDB06142) A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor.
Rats KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts.
Rats Does the beta2-agonist clenbuterol help to maintain myocardial potential to recover during mechanical unloading?
Silkworms [Drug discovery for treatment against diabetes by using hyperglycemic silkworms].
Silkworms [Silkworm as a model animal for drug development].
Mice C57BL-p53+/-(RBRC01361) Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts.
DNA material Genome Network human cDNA clone IRAL015K15 (HGY086255) , IRAL037F09 (HGY094929) , IRAK022O02 (HGX009138) , IRAL007N16 (HGY083128) , IRAL016K22 (HGY086662) , IRAL005A23 (HGY082023) , IRAK004O20 (HGX001956) , IRAL006E09 (HGY082505) , IRAL004F23 (HGY081743) A practical fluorogenic substrate for high-throughput screening of glutathione S-transferase inhibitors.
Silkworms Silkworm fungal infection model for identification of virulence genes in pathogenic fungus and screening of novel antifungal drugs.
Silkworms [Development of Antibiotics Using Silkworm Bacteria and Fungi Infection Model].
Pathogenic microorganisms IFM 40005 , IFM 40006 , IFM 40007 , IFM 40009 Studies on peptide antibiotics, leucinostatins. I. Separation, physico-chemical properties and biological activities of leucinostatins A and B.
C.elegans tm4867 , tm4152 , tm1811 , tm355 In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding.
Prokaryotes E. coli NA Endogenous ethanol affects biopolyester molecular weight in recombinant Escherichia coli.
DNA material pLL3.7 K122 FH-TAZ-ires-GFP-TEAD-responsive-H2B mCherry (RDB13967) , pFLAG-human yes-associated protein (YAP)1 (RDB13968) , pClneoMyc-LATS1 (RDB13969) , pClneoMyc-LATS2 (RDB13970) , pClneoLuc-PP1A (RDB13971) , pClneoLuc-PP2A (RDB13972). A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells.
C.elegans tm3223 Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.
Japanese macaques Pharmacokinetic and Safety Evaluation of a Transscleral Sustained Unoprostone Release Device in Monkey Eyes.
Yeast BY25929 Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae.
C.elegans tm2805 Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy.
General Microbes JCM 3224 , JCM 3288 , JCM 3359 , JCM 4826 , JCM 6044 Antimicrobial activity screening of some sulfonamide derivatives on some Nocardia species and isolates.