Reference - Detail
| RRC ID | 31888 |
|---|---|
| Author | Speitling M, Nattewan P, Yazawa K, Mikami Y, Grün-Wollny I, Ritzau M, Laatsch H, Gräfe U. |
| Title | Demethyl mutactimycins, new anthracycline antibiotics from Nocardia and Streptomyces strains. |
| Journal | J Antibiot (Tokyo) |
| Abstract |
New anthracycline antibiotics 3'-O-demethyl mutactimycin (3) and 4-O,3'-O-didemethyl mutactimycin (4) were isolated from two actinomycetes strains, Nocardia transvalensis and Streptomyces sp. GW 60/1571. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy. Antibiotic 3 displayed moderate antimicrobial activity against Gram-positive bacteria and cytotoxicity against P388, L1210 and HeLa tumor cells (IC50; 9.6, >25 and 20 microg/ml, respectively). |
| Volume | 51(8) |
| Pages | 693-8 |
| Published | 1998-8-1 |
| DOI | 10.7164/antibiotics.51.693 |
| PMID | 9766460 |
| MeSH | Animals Anthracyclines* Antibiotics, Antineoplastic / chemistry Antibiotics, Antineoplastic / isolation & purification* Antibiotics, Antineoplastic / pharmacology* Fermentation Gram-Positive Bacteria / drug effects HeLa Cells / drug effects Humans Leukemia L1210 / drug therapy Leukemia P388 / drug therapy Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Nocardia Stereoisomerism Streptomyces Structure-Activity Relationship |
| IF | 2.668 |
| Times Cited | 11 |
| WOS Category | PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY IMMUNOLOGY MICROBIOLOGY |
| Altmetric score |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic microorganisms | IFM 0456 IFM 20572057 |