| RRC ID |
31888
|
| Author |
Speitling M, Nattewan P, Yazawa K, Mikami Y, Grün-Wollny I, Ritzau M, Laatsch H, Gräfe U.
|
| Title |
Demethyl mutactimycins, new anthracycline antibiotics from Nocardia and Streptomyces strains.
|
| Journal |
J Antibiot (Tokyo)
|
| Abstract |
New anthracycline antibiotics 3'-O-demethyl mutactimycin (3) and 4-O,3'-O-didemethyl mutactimycin (4) were isolated from two actinomycetes strains, Nocardia transvalensis and Streptomyces sp. GW 60/1571. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy. Antibiotic 3 displayed moderate antimicrobial activity against Gram-positive bacteria and cytotoxicity against P388, L1210 and HeLa tumor cells (IC50; 9.6, >25 and 20 microg/ml, respectively).
|
| Volume |
51(8)
|
| Pages |
693-8
|
| Published |
1998-8-1
|
| DOI |
10.7164/antibiotics.51.693
|
| PMID |
9766460
|
| MeSH |
Animals
Anthracyclines*
Antibiotics, Antineoplastic / chemistry
Antibiotics, Antineoplastic / isolation & purification*
Antibiotics, Antineoplastic / pharmacology*
Fermentation
Gram-Positive Bacteria / drug effects
HeLa Cells / drug effects
Humans
Leukemia L1210 / drug therapy
Leukemia P388 / drug therapy
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Nocardia
Stereoisomerism
Streptomyces
Structure-Activity Relationship
|
| IF |
2.668
|
| Times Cited |
11
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
IMMUNOLOGY
MICROBIOLOGY
|
| Resource |
| Pathogenic microorganisms |
IFM 0456
IFM 20572057 |
