Reference - Detail
| RRC ID | 31894 |
|---|---|
| Author | Yazawa K, Mikami Y, Maeda A, Morisaki N, Iwasaki S. |
| Title | Phosphorylative inactivation of rifampicin by Nocardia otitidiscaviarum. |
| Journal | J Antimicrob Chemother |
| Abstract |
Rifampicin was inactivated by Nocardia otitidiscaviarum to yield two products designated RIP-3 and RIP-4. The full structures of RIP-3 and RIP-4 were determined to be 21-(O-phosphoryl) rifampicin and 3-formyl-21-(O-phosphoryl) rifamycin SV, respectively, but neither product had any antimicrobial activity. |
| Volume | 33(6) |
| Pages | 1127-35 |
| Published | 1994-6-1 |
| DOI | 10.1093/jac/33.6.1127 |
| PMID | 7928806 |
| MeSH | Biotransformation Corynebacterium / drug effects Drug Resistance, Microbial Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Nocardia / drug effects Nocardia / metabolism* Phosphorylation Rhodococcus / drug effects Rifampin / analogs & derivatives Rifampin / chemistry Rifampin / metabolism* Rifampin / pharmacokinetics* Rifampin / pharmacology Staphylococcus aureus / drug effects |
| IF | 5.439 |
| Times Cited | 31 |
| WOS Category | PHARMACOLOGY & PHARMACY INFECTIOUS DISEASES MICROBIOLOGY |
| Resource | |
| Pathogenic microorganisms | IFM 0150 IFM 0236 IFM 0239 IFM 0290 IFM 0319 IFM 2057 |