論文 - 詳細
| RRC ID | 31904 |
|---|---|
| 著者 | Krapp A, Simanis V. |
| タイトル | Dma1-dependent degradation of SIN proteins during meiosis in Schizosaccharomyces pombe. |
| ジャーナル | J Cell Sci |
| Abstract |
The Schizosaccharomyces pombe septation initiation network (SIN) is required for cytokinesis during vegetative growth and for spore formation during meiosis. Regulation of the SIN during mitosis has been studied extensively, but less is known about its meiotic regulation. Here, we show that several aspects of SIN regulation differ between mitosis and meiosis. First, the presence of GTP-bound Spg1p is not the main determinant of the timing of Cdc7p and Sid1p association with the spindle pole body (SPB) during meiosis. Second, the localisation dependencies of SIN proteins differ from those in mitotic cells, suggesting a modified functional organisation of the SIN during meiosis. Third, there is stage-specific degradation of SIN components in meiosis; Byr4p is degraded after meiosis I, whereas the degradation of Cdc7p, Cdc11p and Sid4p occurs after the second meiotic division and depends upon the ubiquitin ligase Dma1p. Finally, Dma1p-dependent degradation is not restricted to the SIN, as we show that Dma1p is needed for the degradation of Mcp6p (also known as Hrs1p) during meiosis I. Taken together, these data suggest that stage-specific targeted proteolysis plays an important role in regulating meiotic progression. |
| 巻・号 | 127(Pt 14) |
| ページ | 3149-61 |
| 公開日 | 2014-7-15 |
| DOI | 10.1242/jcs.148585 |
| PII | jcs.148585 |
| PMID | 24838944 |
| MeSH | Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism* Meiosis / physiology* Repressor Proteins / metabolism Schizosaccharomyces / cytology* Schizosaccharomyces / metabolism Schizosaccharomyces pombe Proteins / genetics Schizosaccharomyces pombe Proteins / metabolism* Signal Transduction |
| IF | 4.573 |
| 引用数 | 3 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | FYP1017(GFP-Psy1) |