RRC ID 31926
Author Fukai T, Yonekawa M, Hou AJ, Nomura T, Sun HD, Uno J.
Title Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species.
Journal J. Nat. Prod.
Abstract Bioassay-guided fractionation resulted in the isolation of four antifungal agents from the roots of Cudrania cochinchinensis. Two of these were new compounds, cudraxanthone S [1, 1,3,5,6-tetrahydroxy-2-(1,1-dimethyl-2-propenyl)xanthone] and cudraflavanone B (2, 2',4',5,7-tetrahydroxy-6-prenylflavanone). The remaining two compounds were known compounds, toxyloxanthone C (3) and wighteone (4). Among these compounds, 1, 3, and 4 exhibited antifungal activities against Cryptococcus neoformans, Aspergillusfumigatus, and A. nidulans (MICs = 2-8 microg/mL). Compounds 1 and 3 also showed antifungal activity against Candida glabrata (MICs = 4-8 microg/mL).
Volume 66(8)
Pages 1118-20
Published 2003-8
DOI 10.1021/np030024u
PMID 12932139
MeSH Antifungal Agents / chemistry Antifungal Agents / isolation & purification* Antifungal Agents / pharmacology Aspergillus / drug effects* Candida / drug effects* Cryptococcus / drug effects* Drugs, Chinese Herbal / chemistry Drugs, Chinese Herbal / isolation & purification* Drugs, Chinese Herbal / pharmacology Molecular Structure Moraceae / chemistry* Plant Roots / chemistry Xanthones / chemistry Xanthones / isolation & purification* Xanthones / pharmacology
IF 3.885
Times Cited 34
WOS Category PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL PLANT SCIENCES
Resource
Pathogenic microorganisms IFM 5369 IFM 5774 IFM 5798 IFM 40205 IFM 40213 IFM 40215 IFM 40217 IFM 41236 IFM 41374 IFM 46829