| RRC ID |
31934
|
| Author |
Tanaka Y, Gräfe U, Yazawa K, Mikami Y, Ritzau M.
|
| Title |
Nocardicyclins A and B: new anthracycline antibiotics produced by Nocardia pseudobrasiliensis.
|
| Journal |
J Antibiot (Tokyo)
|
| Abstract |
Nocardicyclins A (1) and B (2), new anthracycline antibiotics have been isolated from the mycelial cake of Nocardia pseudobrasiliensis IFM 0624 (JCM 9894). The molecular formulae of 1 and 2 have been determined as C30H35NO11 and C32H37NO12, respectively, and the structures were characterized by 1- and 8-methoxyl groups, a 10-carbonyl group and a novel carbon-methylated aminosugar constituent. Nocardicyclin A (1) exerts cytotoxic activity against L1210 and P388 leukemia. Nocardicyclins A (1) and B (2) are active against Gram-positive bacteria including Mycobacterium spp. and Nocardia spp., but inactive against Gram-negative bacteria.
|
| Volume |
50(10)
|
| Pages |
822-7
|
| Published |
1997-10-1
|
| DOI |
10.7164/antibiotics.50.822
|
| PMID |
9402986
|
| MeSH |
Anthracyclines*
Antibiotics, Antineoplastic / chemistry*
Antibiotics, Antineoplastic / metabolism
Antibiotics, Antineoplastic / pharmacology*
Fermentation
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Nocardia / chemistry
Nocardia / metabolism*
|
| IF |
2.668
|
| Times Cited |
31
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
IMMUNOLOGY
MICROBIOLOGY
|
| Resource |
| Pathogenic microorganisms |
IFM 0236
IFM 0239
IFM 0284
IFM 0290
IFM 0319
IFM 0333
IFM 0623
IFM 0624
IFM 40213 |
