Reference - Detail
|Author||Nemoto A, Tanaka Y, Karasaki Y, Komaki H, Yazawa K, Mikami Y, Tojo T, Kadowaki K, Tsuda M, Kobayashi J.|
|Title||Brasiliquinones A, B and C, new benz[alpha]anthraquinone antibiotics from Nocardia brasiliensis. I. Producing strain, isolation and biological activities of the antibiotics.|
New benz[alpha]anthraquinone antibiotics (brasiliquinones A, B and C) with an ethyl group at C-3 were isolated. The producer was identified as Nocardia brasiliensis. The antibiotics were active against Gram-positive bacteria including Mycobacterium sp., but not active against Gram-negative bacteria or fungi. They were also active against multiple drug-resistant P388/ADR tumor cells.
|MeSH||Animals Anthraquinones / isolation & purification Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / isolation & purification* Anti-Bacterial Agents / pharmacology Fermentation Mice Nocardia / classification Nocardia / metabolism* Tumor Cells, Cultured|
|WOS Category||PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY IMMUNOLOGY MICROBIOLOGY|
|Pathogenic microorganisms||IFM 0089 IFM 40213|