Reference - Detail
| RRC ID | 31955 |
|---|---|
| Author | Park S, Sonn JY, Oh Y, Lim C, Choe J. |
| Title | SIFamide and SIFamide receptor defines a novel neuropeptide signaling to promote sleep in Drosophila. |
| Journal | Mol Cells |
| Abstract |
SIFamide receptor (SIFR) is a Drosophila G protein-coupled receptor for the neuropeptide SIFamide (SIFa). Although the sequence and spatial expression of SIFa are evolutionarily conserved among insect species, the physiological function of SIFa/SIFR signaling remains elusive. Here, we provide genetic evidence that SIFa and SIFR promote sleep in Drosophila. Either genetic ablation of SIFa-expressing neurons in the pars intercerebralis (PI) or pan-neuronal depletion of SIFa expression shortened baseline sleep and reduced sleep-bout length, suggesting that it caused sleep fragmentation. Consistently, RNA interference- mediated knockdown of SIFR expression caused short sleep phenotypes as observed in SIFa-ablated or depleted flies. Using a panel of neuron-specific Gal4 drivers, we further mapped SIFR effects to subsets of PI neurons. Taken together, these results reveal a novel physiological role of the neuropeptide SIFa/SIFR pathway to regulate sleep through sleep-promoting neural circuits in the PI of adult fly brains. |
| Volume | 37(4) |
| Pages | 295-301 |
| Published | 2014-4-1 |
| DOI | 10.14348/molcells.2014.2371 |
| PII | molcells.2014.2371 |
| PMID | 24658384 |
| PMC | PMC4012077 |
| MeSH | Animals Animals, Genetically Modified Drosophila* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Female Male Neurons / physiology* Neuropeptides / metabolism* Pituitary Gland, Intermediate / pathology* RNA, Small Interfering / genetics Receptors, Neuropeptide / genetics Receptors, Neuropeptide / metabolism* Signal Transduction / genetics Sleep* / genetics Sleep Deprivation / genetics Sleep Deprivation / metabolism* Transcription Factors / genetics |
| IF | 4.081 |
| Times Cited | 39 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | 10823R-1 |