RRC ID 31956
Author Ito S, Ueda T, Ueno A, Nakagawa H, Taniguchi H, Kayukawa N, Miki T.
Title A genetic screen in Drosophila for regulators of human prostate cancer progression.
Journal Biochem Biophys Res Commun
Abstract To uncover the mechanism by which human prostate cancer progresses, we performed a genetic screen for regulators of human prostate cancer progression using the Drosophila accessory gland, a functional homolog of the mammalian prostate. Cell growth and migration of secondary cells in the adult male accessory gland were found to be regulated by paired, N-cadherin, and E-cadherin, which are Drosophila homologues of regulators of human prostate cancer progression. Using this screening system, we also identified three genes that promoted growth and migration of secondary cells in the accessory gland. The human homologues of these candidate genes - MRGBP, CNPY2, and MEP1A - were found to be expressed in human prostate cancer model cells and to promote replication and invasiveness in these cells. These findings suggest that the development of the Drosophila accessory gland and human prostate cancer cell growth and invasion are partly regulated through a common mechanism. The screening system using the Drosophila accessory gland can be a useful tool for uncovering the mechanisms of human prostate cancer progression.
Volume 451(4)
Pages 548-55
Published 2014-9-5
DOI 10.1016/j.bbrc.2014.08.015
PII S0006-291X(14)01421-1
PMID 25117438
MeSH Adaptor Proteins, Signal Transducing / genetics Adaptor Proteins, Signal Transducing / physiology Animals Carrier Proteins / genetics Carrier Proteins / physiology Cell Line, Tumor Cell Movement / genetics Disease Progression* Exocrine Glands / chemistry Histone Acetyltransferases Humans Male Metalloendopeptidases / genetics Metalloendopeptidases / physiology Neoplasm Invasiveness / physiopathology Nuclear Proteins Prostatic Neoplasms / physiopathology*
IF 2.705
Times Cited 20
Drosophila 1462R-2 9968R-1 5562R-3 9148R-2 12918R-2 6223R-2 5862R-1 4164R-4 7225R-1 5112R-1 4623R-3 5170R-1 5183R-1 31872R-2 17271R-1 11864R-2 3153R-3 9720R-2 1418R-1 1316R-1 8137R-2 11785R-2 11642R-3 7830R-1 13746R-2 6716R-1 3722R-2 7100R-3