| RRC ID |
31965
|
| 著者 |
Mao F, Yang X, Fu L, Lv X, Zhang Z, Wu W, Yang S, Zhou Z, Zhang L, Zhao Y.
|
| タイトル |
The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway.
|
| ジャーナル |
J Biol Chem
|
| Abstract |
The hedgehog (Hh) signaling pathway plays a very important role in metazoan development by controlling pattern formation. Drosophila imaginal discs are subdivided into anterior and posterior compartments that derive from adjacent cell populations. The anterior/posterior (A/P) boundaries, which are critical to maintaining the position of organizers, are established by a complex mechanism involving Hh signaling. Here, we uncover the regulation of ptc in the Hh signaling pathway by two subunits of mediator complex, Kto and Skd, which can also regulate boundary location. Collectively, we provide further evidence that Kto-Skd affects the A/P-axial development of the whole wing disc. Kto can interact with Cubitus interruptus (Ci), bind to the Ci-binding region on ptc promoter, which are both regulated by Hh signals to down-regulate ptc expression.
|
| 巻・号 |
289(32)
|
| ページ |
22333-41
|
| 公開日 |
2014-8-8
|
| DOI |
10.1074/jbc.M114.560995
|
| PII |
S0021-9258(20)33167-7
|
| PMID |
24962581
|
| PMC |
PMC4139242
|
| MeSH |
Animals
Animals, Genetically Modified
Body Patterning
DNA-Binding Proteins / metabolism*
Drosophila Proteins / genetics*
Drosophila Proteins / metabolism*
Drosophila melanogaster / genetics
Drosophila melanogaster / growth & development*
Drosophila melanogaster / metabolism*
Eye Proteins / genetics
Eye Proteins / metabolism*
Gene Expression Regulation, Developmental
Genes, Insect
Hedgehog Proteins / genetics
Hedgehog Proteins / metabolism*
Multiprotein Complexes / metabolism
Mutation
Promoter Regions, Genetic
Receptors, Cell Surface / genetics*
Signal Transduction
Transcription Factors / metabolism*
Wings, Animal / growth & development
Wings, Animal / metabolism
|
| IF |
4.238
|
| 引用数 |
6
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
8491R-1
9936R-3
10572R-1 |
