RRC ID 31965
Author Mao F, Yang X, Fu L, Lv X, Zhang Z, Wu W, Yang S, Zhou Z, Zhang L, Zhao Y.
Title The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway.
Journal J. Biol. Chem.
Abstract The hedgehog (Hh) signaling pathway plays a very important role in metazoan development by controlling pattern formation. Drosophila imaginal discs are subdivided into anterior and posterior compartments that derive from adjacent cell populations. The anterior/posterior (A/P) boundaries, which are critical to maintaining the position of organizers, are established by a complex mechanism involving Hh signaling. Here, we uncover the regulation of ptc in the Hh signaling pathway by two subunits of mediator complex, Kto and Skd, which can also regulate boundary location. Collectively, we provide further evidence that Kto-Skd affects the A/P-axial development of the whole wing disc. Kto can interact with Cubitus interruptus (Ci), bind to the Ci-binding region on ptc promoter, which are both regulated by Hh signals to down-regulate ptc expression.
Volume 289(32)
Pages 22333-41
Published 2014-8-8
DOI 10.1074/jbc.M114.560995
PII M114.560995
PMID 24962581
PMC PMC4139242
MeSH Animals Animals, Genetically Modified Body Patterning DNA-Binding Proteins / metabolism* Drosophila Proteins / genetics* Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development* Drosophila melanogaster / metabolism* Eye Proteins / genetics Eye Proteins / metabolism* Gene Expression Regulation, Developmental Genes, Insect Hedgehog Proteins / genetics Hedgehog Proteins / metabolism* Multiprotein Complexes / metabolism Mutation Promoter Regions, Genetic Receptors, Cell Surface / genetics* Signal Transduction Transcription Factors / metabolism* Wings, Animal / growth & development Wings, Animal / metabolism
IF 4.106
Times Cited 4
Drosophila 8491R-1 9936R-3 10572R-1